Cardiovascular effects of erythropoietin. An update

Anantha Vijay R. Santhanam, Livius V. d'Uscio, Zvonimir S. Katusic

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

Erythropoietin (EPO) is a therapeutic product of recombinant DNA technology and it has been in clinical use as stimulator of erythropoiesis over the last two decades. Identification of EPO and its receptor (EPOR) in the cardiovascular system expanded understanding of physiological and pathophysiological role of EPO. In experimental models of cardiovascular and cerebrovascular disorders, EPO exerts protection either by preventing apoptosis of cardiac myocytes, smooth muscle cells, and endothelial cells, or by increasing endothelial production of nitric oxide. In addition, EPO stimulates mobilization of progenitor cells from bone marrow thereby accelerating repair of injured endothelium and neovascularization. A novel signal transduction pathway involving EPOR-β-common heteroreceptor is postulated to enhance EPO-mediated tissue protection. A better understanding of the role of β-common receptor signaling as well as development of novel analogs of EPO with enhanced nonhematopoietic protective effects may expand clinical application of EPO in prevention and treatment of cardiovascular and cerebrovascular disorders.

Original languageEnglish (US)
Title of host publicationAdvances in Pharmacology
PublisherAcademic Press Inc
Pages257-285
Number of pages29
EditionC
DOIs
StatePublished - 2010

Publication series

NameAdvances in Pharmacology
NumberC
Volume60
ISSN (Print)1054-3589

Keywords

  • Akt
  • Endothelium
  • ENOS
  • Erythropoietin

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Santhanam, A. V. R., d'Uscio, L. V., & Katusic, Z. S. (2010). Cardiovascular effects of erythropoietin. An update. In Advances in Pharmacology (C ed., pp. 257-285). (Advances in Pharmacology; Vol. 60, No. C). Academic Press Inc. https://doi.org/10.1016/B978-0-12-385061-4.00009-X