Cardiovascular Disease Burden and Risk Factors Before and After Kidney Transplant

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cardiovascular (CV) disease is the most common cause of mortality among kidney transplant candidates on the waiting-list and after kidney transplantation. The mechanisms of cardiovascular disease burden after transplant are multifactorial and the risk is largely determined by pre-transplant factors including CV disease and dialysis duration. Current pre-transplant cardiac evaluation protocols have proven to be inconsistent in predicting adverse cardiovascular outcome post-transplant. However, multiple biomarkers have been recognized as predictors of all-cause mortality and cardiovascular events including graft function, hemoglobin, homocysteine, C - reactive protein among others. Of these, elevation in the biomarker cardiac troponin T appears to be a significant predictor of cardiovascular events and mortality among wait-listed kidney transplant candidates and after transplantation. The relationship between CV risk reduction, normalization of cardiac troponin T levels and restoration of renal function after kidney transplant is complex but opens opportunities for the use of cardiac troponin T and other cardiovascular biomarkers as important endpoints of clinical interventions in kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalCardiovascular and Hematological Disorders - Drug Targets
Volume14
Issue number3
StatePublished - Jan 1 2014

Fingerprint

Cardiovascular Diseases
Transplants
Kidney
Troponin T
Biomarkers
Mortality
Hemoglobin C
Waiting Lists
Homocysteine
Risk Reduction Behavior
C-Reactive Protein
Kidney Transplantation
Dialysis
Transplantation

Keywords

  • Cardiovascular disease
  • Kidney transplant
  • Risk factors

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Hematology
  • Pharmacology

Cite this

Cardiovascular Disease Burden and Risk Factors Before and After Kidney Transplant. / Keddis, Mira; Bhutani, Gauri; El-Zoghby, Ziad M.

In: Cardiovascular and Hematological Disorders - Drug Targets, Vol. 14, No. 3, 01.01.2014, p. 185-194.

Research output: Contribution to journalArticle

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