Cardiovascular disease

Anant Khositseth, Michael John Ackerman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

During the last decade, techniques and advances in molecular genetics and genomics have yielded profound new insights into the fundamental mechanisms and genetic underpinnings for many heritable cardiovascular diseases. The resulting genotype-phenotype correlations facilitate: (1) molecular testing for the preclinical/presymptomatic identification of genetically susceptible individuals, (2) the possibility of gene-based prognosis, and (3) new opportunities for gene-specific or gene-targeted therapy including primary prevention in genotype-positive-phenotypenegative individuals. Cardiology has embraced new genetic discoveries, since sudden cardiac death (SCD) consumes more lives than any other medical condition in developed countries, with 1,000 SCDs occurring each day in the United States. Coronary artery disease (CAD) is the major cause of SCD, while other heritable processes including cardiomyopathies and the channelopathies may also predispose to fatal ventricular arrhythmias.

Original languageEnglish (US)
Title of host publicationMolecular Pathology in Clinical Practice
PublisherSpringer New York
Pages161-177
Number of pages17
ISBN (Print)038733226X, 9780387332260
DOIs
StatePublished - 2007

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Sudden Cardiac Death
Cardiovascular Diseases
Channelopathies
Genetic Association Studies
Primary Prevention
Genomics
Cardiology
Cardiomyopathies
Developed Countries
Genetic Therapy
Genes
Cardiac Arrhythmias
Coronary Artery Disease
Molecular Biology
Genotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Khositseth, A., & Ackerman, M. J. (2007). Cardiovascular disease. In Molecular Pathology in Clinical Practice (pp. 161-177). Springer New York. https://doi.org/10.1007/978-0-387-33227-7_14

Cardiovascular disease. / Khositseth, Anant; Ackerman, Michael John.

Molecular Pathology in Clinical Practice. Springer New York, 2007. p. 161-177.

Research output: Chapter in Book/Report/Conference proceedingChapter

Khositseth, A & Ackerman, MJ 2007, Cardiovascular disease. in Molecular Pathology in Clinical Practice. Springer New York, pp. 161-177. https://doi.org/10.1007/978-0-387-33227-7_14
Khositseth A, Ackerman MJ. Cardiovascular disease. In Molecular Pathology in Clinical Practice. Springer New York. 2007. p. 161-177 https://doi.org/10.1007/978-0-387-33227-7_14
Khositseth, Anant ; Ackerman, Michael John. / Cardiovascular disease. Molecular Pathology in Clinical Practice. Springer New York, 2007. pp. 161-177
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