Cardiovascular consequences of obstructive sleep apnoea

Fatima H.Sert Kuniyoshi, Snigdha Pusalavidyasagar, Prachi Singh, Virend K. Somers

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Obstructive sleep apnoea (OSA) is a form of sleep disordered breathing with a high prevalence rate and is often underdiagnosed. OSA is associated with hypertension, coronary artery disease, stroke, peripheral vascular disease, heart failure, and arrhythmias. The presence of OSA may be a strong predictor of fatal cardiovascular events in patients with cardiovascular disease (CVD). Increased sympathetic drive, activation of metabolic and inflammatory markers, and impaired vascular function are some of the proposed mechanisms that could explain the association between OSA and cardiovascular diseases. Understanding these mechanisms is important for identifying treatment strategies. The presence of OSA should be considered in clinical practice, especially in patients with CVD. Randomized intervention studies are needed to establish whether early identification and treatment of OSA patients reduces cardiovascular morbidity.

Original languageEnglish (US)
Pages (from-to)196-205
Number of pages10
JournalIndian Journal of Medical Research
Volume131
Issue number2
StatePublished - Feb 1 2010

Keywords

  • CPAP
  • Cardiac arrhythmias
  • Cardiovascular risk
  • Ischaemia
  • Myocardial infarction
  • OSA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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