Cardiovascular Comorbidity in Rheumatic Diseases: A Focus on Heart Failure

Kerry Wright, Cynthia S. Crowson, Sherine E. Gabriel

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Rheumatic diseases are associated with an increased risk of cardiovascular (CV) mortality attributed to a higher incidence of heart failure (HF) and ischemic heart disease. Although traditional CV risk factors contribute to the increased incidence seen in this population, by themselves they do not account for the increased risk; in fact, obesity and hyperlipidemia may play a paradoxic role. Immune-mediated mechanisms and chronic inflammation likely play a role in the pathogenesis of CV disease in patients with rheumatic diseases. The usual clinical features of ischemic heart disease and HF are less likely to be seen in this patient population.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalHeart Failure Clinics
Volume10
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Cardiovascular disease
  • Heart failure
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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