Cardiovascular and Valsalva responses during parabolic flight

Todd T. Schlegel, Edgar W. Benavides, Donald C. Barker, Troy E. Brown, Deborah L. Harm, Suresh J. Desilva, Phillip Anson Low

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We investigated the integrated cardiovascular responses of 15 human subjects to the acute gravitational changes (micro- and hypergravity portions) of parabolic flight. Measurements were made with subjects quietly seated and while subjects performed controlled Valsalva maneuvers. During quiet, seated, parabolic flight, mean arterial pressure increased during the transition into microgravity but decreased as microgravity was sustained. The decrease in mean arterial pressure was accompanied by immediate reflexive increases in heart rate but by absent (or later-than-expected) reflexive increases in total vascular resistance. Mean arterial pressure responses in Valsalva phases II, III, and IV were accentuated in hypergravity relative to microgravity (P < 0.01, P < 0.01, and P < 0.05, respectively), but accentuations differed qualitatively and quantitatively from those induced by a supine-to-seated postural change in 1 G. This study is the first systematic evaluation of temporal and Valsalva-related changes in cardiovascular parameters during parabolic flight. Results suggest that arterial baroreflex control of vascular resistance may be modified by alterations of cardiopulmonary, vestibular, and/or other receptor activity.

Original languageEnglish (US)
Pages (from-to)1957-1965
Number of pages9
JournalJournal of Applied Physiology
Volume85
Issue number5
StatePublished - Nov 1998

Fingerprint

Weightlessness
Hypergravity
Arterial Pressure
Vascular Resistance
Valsalva Maneuver
Baroreflex
Heart Rate

Keywords

  • Baroreflex
  • Hypergravity
  • Microgravity
  • Valsalva maneuver

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Schlegel, T. T., Benavides, E. W., Barker, D. C., Brown, T. E., Harm, D. L., Desilva, S. J., & Low, P. A. (1998). Cardiovascular and Valsalva responses during parabolic flight. Journal of Applied Physiology, 85(5), 1957-1965.

Cardiovascular and Valsalva responses during parabolic flight. / Schlegel, Todd T.; Benavides, Edgar W.; Barker, Donald C.; Brown, Troy E.; Harm, Deborah L.; Desilva, Suresh J.; Low, Phillip Anson.

In: Journal of Applied Physiology, Vol. 85, No. 5, 11.1998, p. 1957-1965.

Research output: Contribution to journalArticle

Schlegel, TT, Benavides, EW, Barker, DC, Brown, TE, Harm, DL, Desilva, SJ & Low, PA 1998, 'Cardiovascular and Valsalva responses during parabolic flight', Journal of Applied Physiology, vol. 85, no. 5, pp. 1957-1965.
Schlegel TT, Benavides EW, Barker DC, Brown TE, Harm DL, Desilva SJ et al. Cardiovascular and Valsalva responses during parabolic flight. Journal of Applied Physiology. 1998 Nov;85(5):1957-1965.
Schlegel, Todd T. ; Benavides, Edgar W. ; Barker, Donald C. ; Brown, Troy E. ; Harm, Deborah L. ; Desilva, Suresh J. ; Low, Phillip Anson. / Cardiovascular and Valsalva responses during parabolic flight. In: Journal of Applied Physiology. 1998 ; Vol. 85, No. 5. pp. 1957-1965.
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