Cardiovascular and renal actions of C-type natriuretic peptide

A. J. Stingo, A. L. Clavell, L. L. Aarhus, John C Jr. Burnett

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng·kg-1·min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac output, and atrial pressures in association with a decrease in sodium excretion. Bolus administration of CNP (group 2; 5 μg/kg iv) to minimize cardiovascular hemodynamic changes resulted in only a transient decrease in arterial pressure. Sodium excretion decreased despite a return of arterial pressure to baseline. These biological responses were associated with increases in plasma guanosine 3',5'-cyclic monophosphate (cGMP) in both groups but with no change in urinary cGMP. With both systemic infusion or bolus administration of CNP, significant increases in plasma aldosterone were observed in association with increases in distal nephron sodium reabsorption. This study demonstrates that CNP exhibits profound systemic hemodynamic actions and is indirectly, or perhaps directly, antinatriuretic.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number1 31-1
StatePublished - 1992

Fingerprint

C-Type Natriuretic Peptide
Kidney
Arterial Pressure
Hemodynamics
Sodium
Atrial Pressure
Nephrons
Cyclic GMP
Aldosterone
Cardiac Output
Dogs

Keywords

  • C-type natriuretic peptide
  • Mean arterial pressure
  • Renal sodium excretion

ASJC Scopus subject areas

  • Physiology

Cite this

Cardiovascular and renal actions of C-type natriuretic peptide. / Stingo, A. J.; Clavell, A. L.; Aarhus, L. L.; Burnett, John C Jr.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 1 31-1, 1992.

Research output: Contribution to journalArticle

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