Cardiovascular and renal actions of C-type natriuretic peptide

A. J. Stingo, A. L. Clavell, L. L. Aarhus, J. C. Burnett

Research output: Contribution to journalArticle

146 Scopus citations

Abstract

Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng·kg-1·min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac output, and atrial pressures in association with a decrease in sodium excretion. Bolus administration of CNP (group 2; 5 μg/kg iv) to minimize cardiovascular hemodynamic changes resulted in only a transient decrease in arterial pressure. Sodium excretion decreased despite a return of arterial pressure to baseline. These biological responses were associated with increases in plasma guanosine 3',5'-cyclic monophosphate (cGMP) in both groups but with no change in urinary cGMP. With both systemic infusion or bolus administration of CNP, significant increases in plasma aldosterone were observed in association with increases in distal nephron sodium reabsorption. This study demonstrates that CNP exhibits profound systemic hemodynamic actions and is indirectly, or perhaps directly, antinatriuretic.

Original languageEnglish (US)
Pages (from-to)H308-H312
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number1 31-1
DOIs
StatePublished - 1992

Keywords

  • C-type natriuretic peptide
  • Mean arterial pressure
  • Renal sodium excretion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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