Abstract
A study was undertaken to determine if normal healthy subjects can increase their endurance capacity consequent to endurance training during chronic β-adrenergic blockade. Forty-seven subjects, 17 to 34 years of age, were randomly assigned to 1 of 3 treatments (placebo, propranolol, 160 mg/day, and atenolol, 100 mg/day) and then completed a 15-week aerobic exercise training program. All groups reduced their submaximal steady-state heart rates consequent to training; submaximal oxygen uptake was slightly reduced; submaximal stroke volume was increased only in the placebo and atenolol groups; submaximal cardiac output was generally lower; and arterial-mixed venous oxygen difference was increased after training in all 3 groups, suggesting decreased muscle blood flow and increased oxidative capacity. Maximal oxygen uptake, and maximal treadmill time were increased in all 3 groups after training. However, while still on medication the atenolol group had significantly greater increases In maximal oxygen uptake and maximal treadmill time compared with the propranolol group. Because most patients will remain on medication, these results suggest a distinct advantage for cardloselective blocking agents. It is concluded that β-adrenergic blockade does not reduce the ability of normal healthy subjects to gain the benefits associated with cardiorespiratory endurance training.
| Original language | English (US) |
|---|---|
| Journal | The American Journal of Cardiology |
| Volume | 55 |
| Issue number | 10 |
| DOIs | |
| State | Published - Apr 26 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Cardiorespiratory alterations consequent to endurance exercise training during chronic beta-adrenergic blockade with atenolol and propranolol. / Wilmore, Jack H.; Ewy, Gordon A.; Freund, Beau J.; Hartzell, Albert A.; Jilka, Sarah M.; Joyner, Michael Joseph; Todd, Carl A.; Kinzer, Scott M.; Pepin, Eric B.
In: The American Journal of Cardiology, Vol. 55, No. 10, 26.04.1985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiorespiratory alterations consequent to endurance exercise training during chronic beta-adrenergic blockade with atenolol and propranolol
AU - Wilmore, Jack H.
AU - Ewy, Gordon A.
AU - Freund, Beau J.
AU - Hartzell, Albert A.
AU - Jilka, Sarah M.
AU - Joyner, Michael Joseph
AU - Todd, Carl A.
AU - Kinzer, Scott M.
AU - Pepin, Eric B.
PY - 1985/4/26
Y1 - 1985/4/26
N2 - A study was undertaken to determine if normal healthy subjects can increase their endurance capacity consequent to endurance training during chronic β-adrenergic blockade. Forty-seven subjects, 17 to 34 years of age, were randomly assigned to 1 of 3 treatments (placebo, propranolol, 160 mg/day, and atenolol, 100 mg/day) and then completed a 15-week aerobic exercise training program. All groups reduced their submaximal steady-state heart rates consequent to training; submaximal oxygen uptake was slightly reduced; submaximal stroke volume was increased only in the placebo and atenolol groups; submaximal cardiac output was generally lower; and arterial-mixed venous oxygen difference was increased after training in all 3 groups, suggesting decreased muscle blood flow and increased oxidative capacity. Maximal oxygen uptake, and maximal treadmill time were increased in all 3 groups after training. However, while still on medication the atenolol group had significantly greater increases In maximal oxygen uptake and maximal treadmill time compared with the propranolol group. Because most patients will remain on medication, these results suggest a distinct advantage for cardloselective blocking agents. It is concluded that β-adrenergic blockade does not reduce the ability of normal healthy subjects to gain the benefits associated with cardiorespiratory endurance training.
AB - A study was undertaken to determine if normal healthy subjects can increase their endurance capacity consequent to endurance training during chronic β-adrenergic blockade. Forty-seven subjects, 17 to 34 years of age, were randomly assigned to 1 of 3 treatments (placebo, propranolol, 160 mg/day, and atenolol, 100 mg/day) and then completed a 15-week aerobic exercise training program. All groups reduced their submaximal steady-state heart rates consequent to training; submaximal oxygen uptake was slightly reduced; submaximal stroke volume was increased only in the placebo and atenolol groups; submaximal cardiac output was generally lower; and arterial-mixed venous oxygen difference was increased after training in all 3 groups, suggesting decreased muscle blood flow and increased oxidative capacity. Maximal oxygen uptake, and maximal treadmill time were increased in all 3 groups after training. However, while still on medication the atenolol group had significantly greater increases In maximal oxygen uptake and maximal treadmill time compared with the propranolol group. Because most patients will remain on medication, these results suggest a distinct advantage for cardloselective blocking agents. It is concluded that β-adrenergic blockade does not reduce the ability of normal healthy subjects to gain the benefits associated with cardiorespiratory endurance training.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021842604&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(85)91071-9
DO - 10.1016/0002-9149(85)91071-9
M3 - Article
C2 - 3993546
AN - SCOPUS:0021842604
VL - 55
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 10
ER -