Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network

Bradley A. Bart, Steven R. Goldsmith, Kerry L. Lee, Margaret May Redfield, G. Michael Felker, Christopher M. O'Connor, Horng Haur Chen, Jean L. Rouleau, Michael M. Givertz, Marc J. Semigran, Douglas Mann, Anita Deswal, David A. Bull, Martin M. Lewinter, Eugene Braunwald

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Worsening renal function is common among patients hospitalized for acute decompensated heart failure (ADHF). When this occurs, subsequent management decisions often pit the desire for effective decongestion against concerns about further worsening renal function. There are no evidence-based treatments or guidelines to assist in these difficult management decisions. Ultrafiltration is a potentially attractive alternative to loop diuretics for the management of fluid overload in patients with ADHF and worsening renal function. Methods and Results: The National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network designed a clinical trial to determine if ultrafiltration results in improved renal function and relief of congestion compared with stepped pharmacologic care when assessed 96 hours after randomization in patients with ADHF and cardiorenal syndrome. Enrollment began in June 2008. This paper describes the rationale and design of the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF). Conclusions: Treating the signs and symptoms of congestion in ADHF is often complicated by worsening renal function. CARRESS-HF compares treatment strategies (ultrafiltration vs stepped pharmacologic care) for the management of worsening renal function in patients with ADHF. The results of the CARRESS-HF trial are expected to provide information and evidence as to the most appropriate approaches for treating this challenging patient population.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalJournal of Cardiac Failure
Volume18
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Heart Failure
Research
Kidney
Ultrafiltration
Cardio-Renal Syndrome
Sodium Potassium Chloride Symporter Inhibitors
National Heart, Lung, and Blood Institute (U.S.)
Random Allocation
Signs and Symptoms
Clinical Trials
Guidelines
Therapeutics
Population

Keywords

  • Cardiorenal syndrome
  • congestion
  • diuretics
  • heart failure
  • ultrafiltration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiorenal rescue study in acute decompensated heart failure : Rationale and design of CARRESS-HF, for the heart failure clinical research network. / Bart, Bradley A.; Goldsmith, Steven R.; Lee, Kerry L.; Redfield, Margaret May; Felker, G. Michael; O'Connor, Christopher M.; Chen, Horng Haur; Rouleau, Jean L.; Givertz, Michael M.; Semigran, Marc J.; Mann, Douglas; Deswal, Anita; Bull, David A.; Lewinter, Martin M.; Braunwald, Eugene.

In: Journal of Cardiac Failure, Vol. 18, No. 3, 03.2012, p. 176-182.

Research output: Contribution to journalArticle

Bart, BA, Goldsmith, SR, Lee, KL, Redfield, MM, Felker, GM, O'Connor, CM, Chen, HH, Rouleau, JL, Givertz, MM, Semigran, MJ, Mann, D, Deswal, A, Bull, DA, Lewinter, MM & Braunwald, E 2012, 'Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network', Journal of Cardiac Failure, vol. 18, no. 3, pp. 176-182. https://doi.org/10.1016/j.cardfail.2011.12.009
Bart, Bradley A. ; Goldsmith, Steven R. ; Lee, Kerry L. ; Redfield, Margaret May ; Felker, G. Michael ; O'Connor, Christopher M. ; Chen, Horng Haur ; Rouleau, Jean L. ; Givertz, Michael M. ; Semigran, Marc J. ; Mann, Douglas ; Deswal, Anita ; Bull, David A. ; Lewinter, Martin M. ; Braunwald, Eugene. / Cardiorenal rescue study in acute decompensated heart failure : Rationale and design of CARRESS-HF, for the heart failure clinical research network. In: Journal of Cardiac Failure. 2012 ; Vol. 18, No. 3. pp. 176-182.
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