TY - JOUR
T1 - Cardiorenal metabolic syndrome in the African diaspora
T2 - Rationale for including chronic kidney disease in the metabolic syndrome definition
AU - Lea, Janice P.
AU - Greene, Eddie L.
AU - Nicholas, Susanne B.
AU - Agodoa, Lawrence
AU - Norris, Keith C.
PY - 2009
Y1 - 2009
N2 - Chronic kidney disease (CKD) is more likely to progress to end-stage renal disease (ESRD) in African Americans while the reasons for this are unclear. The metabolic syndrome is a risk factor for the development of diabetes, cardiovascular disease, and has been recently linked to incident CKD. Historically, fewer African Americans meet criteria for the definition of metabolic syndrome, despite having higher rates of cardiovascular mortality than Caucasians. The presence of microalbuminuria portends increased cardiovascular risks and has been shown to cluster with the metabolic syndrome. We recently reported that proteinuria is a predictor of CKD progression in African American hypertensives with metabolic syndrome. In this review we explore the potential value of including CKD markers - microalbuminuria/proteinuria or low glomerular filtration rate (GFR)-in refining the cluster of factors defined as metabolic syndrome, ie, "cardiorenal metabolic syndrome.".
AB - Chronic kidney disease (CKD) is more likely to progress to end-stage renal disease (ESRD) in African Americans while the reasons for this are unclear. The metabolic syndrome is a risk factor for the development of diabetes, cardiovascular disease, and has been recently linked to incident CKD. Historically, fewer African Americans meet criteria for the definition of metabolic syndrome, despite having higher rates of cardiovascular mortality than Caucasians. The presence of microalbuminuria portends increased cardiovascular risks and has been shown to cluster with the metabolic syndrome. We recently reported that proteinuria is a predictor of CKD progression in African American hypertensives with metabolic syndrome. In this review we explore the potential value of including CKD markers - microalbuminuria/proteinuria or low glomerular filtration rate (GFR)-in refining the cluster of factors defined as metabolic syndrome, ie, "cardiorenal metabolic syndrome.".
KW - Cardiovascular disease
KW - Chronic kidney disease
KW - Ethnic
KW - Metabolic syndrome
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M3 - Article
AN - SCOPUS:80053181684
SN - 1049-510X
VL - 19
SP - S211-S214
JO - Ethnicity and Disease
JF - Ethnicity and Disease
IS - 2 SUPPL.2
ER -