Cardiorenal-endocrine dynamics during and following volume expansion

R. S. Zimmerman, Brooks Sayre Edwards, T. R. Schwab, D. M. Heublein, John C Jr. Burnett

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The relationship between atrial pressure, atrial natriuretic peptide (ANP), the renin-angiotensin-aldosterone system, and renal hemodynamic and excretory function was examined during and following acute 10% body weight saline volume expansion and measurements were made at 3.3, 6.6, and 10% body weight volume expansion in pentobarbital anesthetized dogs (n = 10). Right atrial pressure (RAP), pulmonary capillary wedge pressure (PCWP), fractional excretion of Na (FE(Na)), and ANP all increased in parallel during volume expansion. Plasma renin activity (PRA) and aldosterone decreased in parallel during 10% volume expansion. Following 10% volume expansion, saline was infused at the peak urine flow rate to maintain peak volume expansion. Despite continued saline infusion, RAP, PCWP, and ANP decreased in parallel. In contrast, FE(Na) remained increased, and aldosterone and PRA remained depressed. These studies demonstrate that atrial pressures, ANP, and FE(Na) increase in parallel during volume expansion; this suggests a role for ANP in modulating acute atrial volume overload. During stable volume expansion periods, however, despite a decrease in ANP levels, Na excretion remains elevated, suggesting that non-ANP mechanisms may be important in maintaining natriuresis during stable volume expansion.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume252
Issue number2
StatePublished - 1987

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Atrial Natriuretic Factor
Atrial Pressure
Pulmonary Wedge Pressure
Aldosterone
Renin
Body Weight
Natriuretic Peptides
Natriuresis
Pentobarbital
Renin-Angiotensin System
Hemodynamics
Urine
Dogs
Kidney

ASJC Scopus subject areas

  • Physiology

Cite this

Cardiorenal-endocrine dynamics during and following volume expansion. / Zimmerman, R. S.; Edwards, Brooks Sayre; Schwab, T. R.; Heublein, D. M.; Burnett, John C Jr.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 252, No. 2, 1987.

Research output: Contribution to journalArticle

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