Cardiopulmonary exercise testing in patients with pulmonary hypertension: Clinical recommendations based on a review of the evidence

Sherry O. Pinkstaff, Charles Dwayne Burger, John Daugherty, Samantha Bond, Ross Arena

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Pulmonary hypertension (PH) remains an ominous diagnosis despite advances in pharmacological and surgical therapy. Early and effective diagnosis is important for clinicians making treatment determinations and patients wishing to understand the prognostic implications of their illness. Cardiopulmonary exercise testing (CPX) has the power to reveal the underlying pathophysiological consequences of the disease process. Research, especially over the last 10-15 years, has demonstrated the utility of this tool. Several CPX variables have been shown to be consistently altered in patients with PH and more so as severity of disease increases. However, to further enhance clinical application, additional research is needed to better define optimal CPX measures and associated cutoff values. This paper gives class-based recommendations with associated levels of evidence for the use of CPX in the PH patient population.

Original languageEnglish (US)
Pages (from-to)279-295
Number of pages17
JournalExpert Review of Respiratory Medicine
Volume10
Issue number3
DOIs
StatePublished - Mar 3 2016

Keywords

  • cardiopulmonary exercise testing
  • evidenced-based recommendations
  • minute ventilation/carbon dioxide production slope
  • oxygen consumption
  • partial pressure of end tidal carbon dioxide
  • pulmonary hypertension
  • ventilatory efficiency

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

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