TY - JOUR
T1 - Cardiopulmonary and gas exchange responses to acute strenuous exercise at 1,270 meters in sickle cell trait
AU - Weisman, Idelle M.
AU - Zeballos, R. Jorge
AU - Johnson, Bruce D.
N1 - Funding Information:
From the Department of Clinical Investigation, Sickle Cell Trait Research Project, William Beaumont Army Medical Center, El Paso, Texas. This work was funded through the United States Army Medical Research and Development Command, Fort Detrick, Frederick, Maryland (Log. No. A-3651 and Contract No. DAMD 17-84-G-4024). This work was presented as an abstract at the American Thoracic Society Meeting, May 1985. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. Requests for reprints should be addressed to Dr. ldelle M. Weisman, Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, Texas 79920-5001. Manuscript submitted May 21, 1987, and accepted in revised form November 1, 1987. *Current address: John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin.
PY - 1988/3
Y1 - 1988/3
N2 - The impact of strenuous exercise and environmental hypoxia on sickle cell trait (SCT) remains controversial. To determine if these factors induce cardiopulmonary and gas exchange abnormalities in SCT, healthy, young black male volunteers, 25 with SCT (HbAS) and 16 control subjects (HbAA), were evaluated during incremental and steady-state exercise tests using a cycle ergometer at 1,270 meters and 24°C. Peak incremental exercise values for power (242 ± 7 versus 253 ± 10 watts), oxygen consumption (3.08 ± 0.1 versus 3.26 ± 0.14 liters/minute), heart rate (188 ± 2 versus 189 ± 3 beats/minute), minute ventilation (129 ± 4.6 versus 144 ± 7.7 liters/minute), oxygen pulse (16.4 ± 0.5 versus 17.3 ± 0.8 ml/beat), and respiratory exchange ratio (1.31 ± 0.01 versus 1.33 ± 0.02) revealed no significant differences (p <0.05) between the SCT and control groups, respectively. Peak incremental exercise values for arterial oxygen tension (82 ± 1.7 versus 82 ± 2.2 mm Hg), arterial carbon dioxide tension (32 ± 0.7 versus 31 ± 0.9 mm Hg), and alveolararterial oxygen pressure differences (19 ± 1.4 versus 21 ± 1.9 mm Hg) were similar for the SCT and control groups, respectively. Steadystate exercise results corroborate incremental exercise findings. It is concluded that cardiopulmonary and gas exchange responses to a brief period of strenuous exercise performed at low altitude at 24°C in a well-characterized SCT sample of recruits were within normal limits and comparable to those of a carefully selected control sample.
AB - The impact of strenuous exercise and environmental hypoxia on sickle cell trait (SCT) remains controversial. To determine if these factors induce cardiopulmonary and gas exchange abnormalities in SCT, healthy, young black male volunteers, 25 with SCT (HbAS) and 16 control subjects (HbAA), were evaluated during incremental and steady-state exercise tests using a cycle ergometer at 1,270 meters and 24°C. Peak incremental exercise values for power (242 ± 7 versus 253 ± 10 watts), oxygen consumption (3.08 ± 0.1 versus 3.26 ± 0.14 liters/minute), heart rate (188 ± 2 versus 189 ± 3 beats/minute), minute ventilation (129 ± 4.6 versus 144 ± 7.7 liters/minute), oxygen pulse (16.4 ± 0.5 versus 17.3 ± 0.8 ml/beat), and respiratory exchange ratio (1.31 ± 0.01 versus 1.33 ± 0.02) revealed no significant differences (p <0.05) between the SCT and control groups, respectively. Peak incremental exercise values for arterial oxygen tension (82 ± 1.7 versus 82 ± 2.2 mm Hg), arterial carbon dioxide tension (32 ± 0.7 versus 31 ± 0.9 mm Hg), and alveolararterial oxygen pressure differences (19 ± 1.4 versus 21 ± 1.9 mm Hg) were similar for the SCT and control groups, respectively. Steadystate exercise results corroborate incremental exercise findings. It is concluded that cardiopulmonary and gas exchange responses to a brief period of strenuous exercise performed at low altitude at 24°C in a well-characterized SCT sample of recruits were within normal limits and comparable to those of a carefully selected control sample.
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U2 - 10.1016/0002-9343(88)90256-2
DO - 10.1016/0002-9343(88)90256-2
M3 - Article
C2 - 3348241
AN - SCOPUS:0023970519
VL - 84
SP - 377
EP - 383
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3 PART 1
ER -