Cardiac troponin T in obstructive sleep apnea

Apoor S. Gami, Anna Svatikova, Robert Wolk, Eric J. Olson, Carolyn J. Duenwald, Allan S. Jaffe, Virend K. Somers

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Study objectives: Obstructive sleep apnea (OSA) is associated with nocturnal angina and ST-segment depression, which are relieved by treatment with continuous positive airway pressure (CPAP). We tested the hypothesis that severe nocturnal hypoxia in patients with OSA causes myocyte necrosis as evidenced by increases in cardiac troponin T. Design: Prospective cohort study. Setting: Cardiovascular physiology and sleep research laboratory. Participants: Fifteen male volunteers with coronary artery disease (CAD) and moderate or severe OSA (apnea-hypopnea index [AHI] > 15). Measurements and results: Polysomnography and measurement of serum cardiac troponin T before sleep, after 4 h of untreated OSA, and in the morning after 4 h of treatment with CPAP. The mean AHI for the group was 41 (SD 16), and the mean oxygen saturation nadir during sleep was 83% (SD 8%). All measurements of cardiac troponin T were < 0.010 ng/mL. Conclusions: Despite the fact that some patients with OSA may experience nocturnal ischemia, this study shows that patients with severe OSA and coexisting CAD do not have nightly episodes of myocardial injury detectable by the current-generation cardiac troponin T assay.

Original languageEnglish (US)
Pages (from-to)2097-2100
Number of pages4
JournalChest
Volume125
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Biomarker
  • Coronary artery disease
  • Obstructive sleep apnea
  • Sleep-disordered breathing
  • Troponin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Cardiac troponin T in obstructive sleep apnea'. Together they form a unique fingerprint.

  • Cite this

    Gami, A. S., Svatikova, A., Wolk, R., Olson, E. J., Duenwald, C. J., Jaffe, A. S., & Somers, V. K. (2004). Cardiac troponin T in obstructive sleep apnea. Chest, 125(6), 2097-2100. https://doi.org/10.1378/chest.125.6.2097