Cardiac troponin I: A marker with high specificity for cardiac injury

J. E. Adams, G. S. Bodor, V. G. Davila-Roman, J. A. Delmez, F. S. Apple, J. H. Ladenson, Allan S Jaffe

Research output: Contribution to journalArticle

981 Citations (Scopus)

Abstract

Background. Levels of MBCK can be increased in patients with skeletal muscle injury or renal failure in the absence of myocardial injury, causing diagnostic confusion. This study was designed to determine whether measurement of cardiac troponin I (cTnI), a myocardial regulatory protein with comparable sensitivity to MBCK, has sufficient specificity to clarify the etiology of MBCK elevations in patients with acute or chronic skeletal muscle disease or renal failure. Methods and Results. Of the patients (n=215) studied, 37 had acute skeletal muscle injury, 10 had chronic muscle disease, nine were marathon runners, and 159 were chronic dialysis patients. Patients were evaluated clinically, by ECG and by two-dimensional echocardiography. Total creatine kinase (normal, <170 IU/L) was determined spectrophotometrically, and cTnI (normal, <3.1 ng/mL) and MBCK (normal, <6.7 ng/mL) were determined with specific monoclonal antibodies. Values above the upper reference limit were considered 'elevated.' Elevations of total creatine kinase were common, and elevations of MBCK occurred in 59% of patients with acute muscle injury, 78% of patients with chronic muscle disease and marathon runners, and 3.8% of patients with chronic renal failure. Some of the patients were critically ill; five patients were found to have had myocardial infarctions and one had a myocardial contusion. cTnI was elevated only in these patients. Conclusions. Elevations of cTnI are highly specific for myocardial injury. Use of cTnI should facilitate distinguishing whether elevations of MBCK are due to myocardial or skeletal muscle injury.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalCirculation
Volume88
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Troponin I
Wounds and Injuries
Skeletal Muscle
Creatine Kinase
Muscles
Renal Insufficiency
Chronic Disease
Critical Illness
Chronic Kidney Failure
Echocardiography
Dialysis
Electrocardiography
Myocardial Infarction
Monoclonal Antibodies

Keywords

  • cardiac troponin I
  • creatine kinase

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Adams, J. E., Bodor, G. S., Davila-Roman, V. G., Delmez, J. A., Apple, F. S., Ladenson, J. H., & Jaffe, A. S. (1993). Cardiac troponin I: A marker with high specificity for cardiac injury. Circulation, 88(1), 101-106.

Cardiac troponin I : A marker with high specificity for cardiac injury. / Adams, J. E.; Bodor, G. S.; Davila-Roman, V. G.; Delmez, J. A.; Apple, F. S.; Ladenson, J. H.; Jaffe, Allan S.

In: Circulation, Vol. 88, No. 1, 1993, p. 101-106.

Research output: Contribution to journalArticle

Adams, JE, Bodor, GS, Davila-Roman, VG, Delmez, JA, Apple, FS, Ladenson, JH & Jaffe, AS 1993, 'Cardiac troponin I: A marker with high specificity for cardiac injury', Circulation, vol. 88, no. 1, pp. 101-106.
Adams JE, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH et al. Cardiac troponin I: A marker with high specificity for cardiac injury. Circulation. 1993;88(1):101-106.
Adams, J. E. ; Bodor, G. S. ; Davila-Roman, V. G. ; Delmez, J. A. ; Apple, F. S. ; Ladenson, J. H. ; Jaffe, Allan S. / Cardiac troponin I : A marker with high specificity for cardiac injury. In: Circulation. 1993 ; Vol. 88, No. 1. pp. 101-106.
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