Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)

Amy K. Saenger, Allan S. Jaffe, Richard Body, Paul O. Collinson, Peter A. Kavsak, Carolyn S.P. Lam, Guillaume Lefèvre, Tobjørn Omland, Jordi Ordóñez-Llanos, Kari Pulkki, Fred S. Apple

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.

Original languageEnglish (US)
Pages (from-to)633-640
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume57
Issue number5
DOIs
StatePublished - Apr 1 2019

Keywords

  • biotin
  • hemolysis
  • interferences
  • natriuretic peptide
  • troponin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)'. Together they form a unique fingerprint.

Cite this