Cardiac transplantation in infancy: a model for dissecting immunological function

Marilia Cascalho, Brenda M. Ogle, Raymund R Razonable, Lori J. West, Jeffrey L. Platt

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Abstract: Infants with heart transplants are generally subjected to thymectomy and T cell depletion. In principle, these manipulations should bring about an enduring defect in the structure and function of the T cell compartment. Consistent with that concept, we found that children with heart transplants have profound contraction of the T cell repertoire and higher levels of herpes viruses following infection. Still, these children are generally free of opportunistic infections and other complications expected of those with immunodeficiency. Here we consider these observations and the implications they offer for understanding immune physiology.

Original languageEnglish (US)
JournalPaediatrics and Child Health
Volume18
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 2008

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Immunological Models
Heart Transplantation
T-Lymphocytes
Transplants
Thymectomy
Opportunistic Infections
Virus Diseases

Keywords

  • cardiac transplantation
  • T cell cellular immunity
  • T cell receptor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cardiac transplantation in infancy : a model for dissecting immunological function. / Cascalho, Marilia; Ogle, Brenda M.; Razonable, Raymund R; West, Lori J.; Platt, Jeffrey L.

In: Paediatrics and Child Health, Vol. 18, No. SUPPL. 1, 10.2008.

Research output: Contribution to journalArticle

Cascalho, Marilia ; Ogle, Brenda M. ; Razonable, Raymund R ; West, Lori J. ; Platt, Jeffrey L. / Cardiac transplantation in infancy : a model for dissecting immunological function. In: Paediatrics and Child Health. 2008 ; Vol. 18, No. SUPPL. 1.
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