Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias

Peter J. Schwartz, Michael J. Ackerman

Research output: Contribution to journalReview articlepeer-review


Proper management of patients affected by genetic disorders causing life-threatening arrhythmias is important for several reasons, including even societal ones, given the predominantly young age of those affected. Incorrect management often has dire consequences, ranging from unnecessary psychologic damage for the patients whose life becomes too limited by the fear of sudden death to equally avoidable tragedies when the entire armamentarium of effective therapies is not fully utilized. In this review, we focus primarily on long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) and deal specifically with the clinical impact of the most commonly used cardiac sympathetic denervation (CSD), namely left cardiac sympathetic denervation (LCSD). The two of us have used LCSD in the management of our patients with either LQTS or CPVT for a very long time and have been involved in ∼500 such interventions. It is on the basis of this personal and direct experience that we wish to share our views with clinical cardiologists and electrophysiologists, adult and paediatric, and with genetic cardiologists. We will begin by reviewing the history and rationale underlying sympathetic denervation therapy and will continue with a disease-specific intensification of therapy, and then with a discussion on how the impressive efficacy of LCSD should translate into guideline-directed therapy in both current and future guidelines, in order to upgrade the quality of care in the era of precision medicine.

Original languageEnglish (US)
Pages (from-to)2096-2104
Number of pages9
JournalEuropean heart journal
Issue number22
StatePublished - Jun 7 2022


  • Cardiac sympathetic denervation
  • Catecholaminergic polymorphic ventricular tachycardia
  • Genetic disorders
  • Left cardiac sympathetic denervation
  • Long QT syndrome
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias'. Together they form a unique fingerprint.

Cite this