Cardiac surgery in kidney and liver transplant recipients

Subrato J. Deb, Charles J. Mullany, Patrick S. Kamath, Joseph A. Dearani, Richard C. Daly, Thomas A. Orszulak, Hartzell V. Schaff

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

OBJECTIVE: To evaluate operative management, outcome, and long-term survival in patients with functioning renal and hepatic allografts who underwent cardiac surgery. PATIENTS AND METHODS: We studied all patients who had previously undergone either renal or hepatic transplantation and who subsequently (1936-2001) underwent: cardiac surgery at one institution. Data were obtained by retrospective medical record analysis. RESULTS: The study comprised 47 patients with renal (n=34) and hepatic (n=13) functioning allografts. Median time to cardiac surgery from transplantation was 79 months. The most common procedures were as follows: coronary artery bypass grafting, 22 (47%); aortic valve procedures, 11 (23%); and mitral valve procedures, 5 (11%). One patient (2%) died within 30 days of surgery Renal allograft dysfunction was noted in S renal patients (15%) Immediately after surgery. Two patients required dialysis postoperatively, 1 of whom required continued dialysis on dismissal. Transient allograft dysfunction, as determined by elevated liver enzyme levels, occurred In 6 hepatic patients (46%). However, all hepatic patients had functional allografts on dismissal. Two patients (4%) developed leg wound infections, and 9 (19%) had respiratory complications. No sternal or mediastinal infection occurred. One- and 5-year survival rates (mean ± SEM) for all patient, were 93%±4% and 76%±8%, respectively. Of the renal patients, 1- and 5-year survival rates (mean ± SEM) were 97%±3% and 82%±8%, respectively. One- and 5-year survival rates (mean ± SEM) for hepatic patients were 77%±12% and 69%±13%, respectively. CONCLUSION: Cardiac surgery can be performed safely in kidney and liver transplant recipients, with low early mortality and excellent medium-term survival. In almost all instances, allograft function is well preserved.

Original languageEnglish (US)
Pages (from-to)917-922
Number of pages6
JournalMayo Clinic proceedings
Volume81
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Cardiac surgery in kidney and liver transplant recipients'. Together they form a unique fingerprint.

Cite this