Cardiac resynchronization therapy upregulates cardiac autonomic control

Yong-Mei Cha, Jae Kuen Oh, Chinami Miyazaki, David L. Hayes, Robert F. Rea, Win Kuang Shen, Samuel J Asirvatham, Brad J. Kemp, David O. Hodge, Peng Sheng Chen, Panithaya Chareonthaitawee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cardiac Resynchronization Therapy and Sympathetic Function. Objective: To determine the effect of cardiac resynchronization therapy (CRT) on sympathetic nervous function in heart failure (HF). Background: Neurohormonal dysregulation and cardiac autonomic dysfunction are associated with HF and contribute to HF progression and its poor prognosis. We hypothesized that mechanical resynchronization improves cardiac sympathetic function in HF. Methods: Sixteen consecutive patients receiving CRT for advanced cardiomyopathy and 10 controls were included in this prospective study. NYHA class, 6-minute walk distance, echocardiographic parameters, plasma norepinephrine (NE) were assessed at baseline, 3-month and 6-month follow-up. Cardiac sympathetic function was determined by 123iodine metaiodobenzylguanidine (123I- MIBG) scintigraphy and 24-hour ambulatory electrocardiography. Results: Along with improvement in NYHA class (3.1 ± 0.3 to 2.1 ± 0.4, P < 0.001) and LVEF (23 ± 6% to 33 ± 12%, P < 0.001), delayed heart/mediastinum (H/M) 123I-MIBG ratio increased significantly (1.8 ± 0.7 to 2.1 ± 0.6, P = 0.04) while the H/M 123I-MIBG washout rate decreased significantly (54 ± 25% to 34 ± 24%, P = 0.01) from baseline to 6-month follow-up. The heart rate variability (HRV) measured in SD of normal-to-normal intervals also increased significantly from baseline (82 ± 30 ms) to follow-up (111 ± 32 ms, P = 0.04). The improvement in NYHA after CRT was significantly associated with baseline 123I-MIBG H/M washout rate (r = 0.65, P = 0.03). The improvement in LVESV index was associated with baseline 123I-MIBG delayed H/M ratio (r = -0.67, P = 0.02) and H/M washout rate (r = 0.65, P = 0.03). Conclusion: After CRT, improvements in cardiac symptoms and LV function were accompanied by rebalanced cardiac autonomic control as measured by 123I-MIBG and HRV.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Volume19
Issue number10
DOIs
StatePublished - Oct 2008

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Cardiac Resynchronization Therapy
3-Iodobenzylguanidine
Mediastinum
Up-Regulation
Heart Failure
Heart Rate
Ambulatory Electrocardiography
Cardiomyopathies
Radionuclide Imaging
Norepinephrine
Prospective Studies

Keywords

  • iodine metaiodobenzylguanidine
  • Cardiac resynchronization therapy
  • Cardiomyopathy
  • Heart failure
  • Sympathetic nerve
  • Ventricular dyssynchrony

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Cardiac resynchronization therapy upregulates cardiac autonomic control. / Cha, Yong-Mei; Oh, Jae Kuen; Miyazaki, Chinami; Hayes, David L.; Rea, Robert F.; Shen, Win Kuang; Asirvatham, Samuel J; Kemp, Brad J.; Hodge, David O.; Chen, Peng Sheng; Chareonthaitawee, Panithaya.

In: Journal of Cardiovascular Electrophysiology, Vol. 19, No. 10, 10.2008, p. 1045-1052.

Research output: Contribution to journalArticle

Cha, Y-M, Oh, JK, Miyazaki, C, Hayes, DL, Rea, RF, Shen, WK, Asirvatham, SJ, Kemp, BJ, Hodge, DO, Chen, PS & Chareonthaitawee, P 2008, 'Cardiac resynchronization therapy upregulates cardiac autonomic control', Journal of Cardiovascular Electrophysiology, vol. 19, no. 10, pp. 1045-1052. https://doi.org/10.1111/j.1540-8167.2008.01190.x
Cha, Yong-Mei ; Oh, Jae Kuen ; Miyazaki, Chinami ; Hayes, David L. ; Rea, Robert F. ; Shen, Win Kuang ; Asirvatham, Samuel J ; Kemp, Brad J. ; Hodge, David O. ; Chen, Peng Sheng ; Chareonthaitawee, Panithaya. / Cardiac resynchronization therapy upregulates cardiac autonomic control. In: Journal of Cardiovascular Electrophysiology. 2008 ; Vol. 19, No. 10. pp. 1045-1052.
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abstract = "Cardiac Resynchronization Therapy and Sympathetic Function. Objective: To determine the effect of cardiac resynchronization therapy (CRT) on sympathetic nervous function in heart failure (HF). Background: Neurohormonal dysregulation and cardiac autonomic dysfunction are associated with HF and contribute to HF progression and its poor prognosis. We hypothesized that mechanical resynchronization improves cardiac sympathetic function in HF. Methods: Sixteen consecutive patients receiving CRT for advanced cardiomyopathy and 10 controls were included in this prospective study. NYHA class, 6-minute walk distance, echocardiographic parameters, plasma norepinephrine (NE) were assessed at baseline, 3-month and 6-month follow-up. Cardiac sympathetic function was determined by 123iodine metaiodobenzylguanidine (123I- MIBG) scintigraphy and 24-hour ambulatory electrocardiography. Results: Along with improvement in NYHA class (3.1 ± 0.3 to 2.1 ± 0.4, P < 0.001) and LVEF (23 ± 6{\%} to 33 ± 12{\%}, P < 0.001), delayed heart/mediastinum (H/M) 123I-MIBG ratio increased significantly (1.8 ± 0.7 to 2.1 ± 0.6, P = 0.04) while the H/M 123I-MIBG washout rate decreased significantly (54 ± 25{\%} to 34 ± 24{\%}, P = 0.01) from baseline to 6-month follow-up. The heart rate variability (HRV) measured in SD of normal-to-normal intervals also increased significantly from baseline (82 ± 30 ms) to follow-up (111 ± 32 ms, P = 0.04). The improvement in NYHA after CRT was significantly associated with baseline 123I-MIBG H/M washout rate (r = 0.65, P = 0.03). The improvement in LVESV index was associated with baseline 123I-MIBG delayed H/M ratio (r = -0.67, P = 0.02) and H/M washout rate (r = 0.65, P = 0.03). Conclusion: After CRT, improvements in cardiac symptoms and LV function were accompanied by rebalanced cardiac autonomic control as measured by 123I-MIBG and HRV.",
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AU - Cha, Yong-Mei

AU - Oh, Jae Kuen

AU - Miyazaki, Chinami

AU - Hayes, David L.

AU - Rea, Robert F.

AU - Shen, Win Kuang

AU - Asirvatham, Samuel J

AU - Kemp, Brad J.

AU - Hodge, David O.

AU - Chen, Peng Sheng

AU - Chareonthaitawee, Panithaya

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N2 - Cardiac Resynchronization Therapy and Sympathetic Function. Objective: To determine the effect of cardiac resynchronization therapy (CRT) on sympathetic nervous function in heart failure (HF). Background: Neurohormonal dysregulation and cardiac autonomic dysfunction are associated with HF and contribute to HF progression and its poor prognosis. We hypothesized that mechanical resynchronization improves cardiac sympathetic function in HF. Methods: Sixteen consecutive patients receiving CRT for advanced cardiomyopathy and 10 controls were included in this prospective study. NYHA class, 6-minute walk distance, echocardiographic parameters, plasma norepinephrine (NE) were assessed at baseline, 3-month and 6-month follow-up. Cardiac sympathetic function was determined by 123iodine metaiodobenzylguanidine (123I- MIBG) scintigraphy and 24-hour ambulatory electrocardiography. Results: Along with improvement in NYHA class (3.1 ± 0.3 to 2.1 ± 0.4, P < 0.001) and LVEF (23 ± 6% to 33 ± 12%, P < 0.001), delayed heart/mediastinum (H/M) 123I-MIBG ratio increased significantly (1.8 ± 0.7 to 2.1 ± 0.6, P = 0.04) while the H/M 123I-MIBG washout rate decreased significantly (54 ± 25% to 34 ± 24%, P = 0.01) from baseline to 6-month follow-up. The heart rate variability (HRV) measured in SD of normal-to-normal intervals also increased significantly from baseline (82 ± 30 ms) to follow-up (111 ± 32 ms, P = 0.04). The improvement in NYHA after CRT was significantly associated with baseline 123I-MIBG H/M washout rate (r = 0.65, P = 0.03). The improvement in LVESV index was associated with baseline 123I-MIBG delayed H/M ratio (r = -0.67, P = 0.02) and H/M washout rate (r = 0.65, P = 0.03). Conclusion: After CRT, improvements in cardiac symptoms and LV function were accompanied by rebalanced cardiac autonomic control as measured by 123I-MIBG and HRV.

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KW - iodine metaiodobenzylguanidine

KW - Cardiac resynchronization therapy

KW - Cardiomyopathy

KW - Heart failure

KW - Sympathetic nerve

KW - Ventricular dyssynchrony

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