Cardiac resynchronization therapy in patients with end-stage hypertrophic cardiomyopathy

Ammar M. Killu, Jae Yoon Park, Jaskanwal D. Sara, David O. Hodge, Bernard J. Gersh, Rick A. Nishimura, Samuel J Asirvatham, Christopher J. McLeod

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. The Mayo Clinic HCM database was interrogated to identify patients with ejection fraction (EF)<50% and CRT. Control subjects were identified in 1:1 manner. Clinical outcomes were determined. Of 2073 patients with HCM, 9 (8 male) had EF<50% and received CRT. The average age at CRT-D implant was 44.8±14.8 years, an average of 17.3±10.3 years after HCM diagnosis. The indication for CRT was based on New York Heart Association class≥II symptoms (mean 2.7±0.4) and EF<50% in all patients (EF 34.7±7.1% at implant), with electrocardiographic evidence of abnormal ventricular conduction. At 6-month, 12-month, and long-term follow-up, EF was 39.9±8.4%, 37.9±9.8%, and 33.3±7.6%, respectively (P>0.05 for all). There was no difference in the combined end-point of left ventricular assist device (LVAD), cardiac transplant, or death between groups (P=0.90). At last follow-up [mean duration 12.9±8.3 (median 10.7) years], 8 (89%) in the CRT group were alive. Three and 2 patients underwent LVAD implantation and cardiac heart transplantation, respectively, 15.0±10.1 years from HCM diagnosis and 2.660.9 years from CRT implant. In the control group, 4 (44.4%) patients were alive at last followup [mean duration 12.0±7.1 (median 12.7) years]. One patient each had LVAD and cardiac transplant. CRT in patients with dilated/end-stage HCM does not appear to confer a salutary effect on ventricular function. In medium-term follow-up, however, left ventricular function did not appear to deteriorate further, yet advanced heart failure therapy was common in this group.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalEuropace
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Biventricular pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Killu, A. M., Park, J. Y., Sara, J. D., Hodge, D. O., Gersh, B. J., Nishimura, R. A., Asirvatham, S. J., & McLeod, C. J. (2018). Cardiac resynchronization therapy in patients with end-stage hypertrophic cardiomyopathy. Europace, 20(1), 82-88. https://doi.org/10.1093/europace/euw327