Cardiac metastasis in renal cell carcinoma without vena cava or atrial involvement

An unusual presentation of metastatic disease

Ben Zhang, Joseph Malouf, Phillip Young, Manish Kohli, Roxana S Dronca

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cardiac metastasis in renal cell carcinoma is a very rare entity, with only a few previously reported cases. In this series, we report two cases of ventricular metastases from renal cell carcinoma without vena cava or right atrial involvement. The first case involves an initially isolated inoperable metastasis to the left ventricle, which was treated with systemic targeted therapy with favorable local response. Our second case illustrates a patient with an isolated cardiac metastasis in the interventricular septum with extension into the right ventricle, which has also remained stable in size on systemic targeted therapy. Although anti-angio-genic agents such as tyrosine kinase inhibitors have transformed the treatment of metastatic renal cell carcinoma in recent years, their efficacy and safety in treating patients with metastatic disease in highly vascular organs such as the heart are currently unknown, with no prior reports on this topic. We describe our novel management of these unique cases and discuss the current medical and surgical approaches to treating cardiac metastases from renal cell carcinoma.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalRare Tumors
Volume5
Issue number3
DOIs
StatePublished - 2013

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Venae Cavae
Renal Cell Carcinoma
Neoplasm Metastasis
Heart Ventricles
Case Management
Protein-Tyrosine Kinases
Blood Vessels
Therapeutics
Safety

Keywords

  • Cardiac metas-tases
  • Renal cell carcinoma
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Histology

Cite this

Cardiac metastasis in renal cell carcinoma without vena cava or atrial involvement : An unusual presentation of metastatic disease. / Zhang, Ben; Malouf, Joseph; Young, Phillip; Kohli, Manish; Dronca, Roxana S.

In: Rare Tumors, Vol. 5, No. 3, 2013, p. 103-105.

Research output: Contribution to journalArticle

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