Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease

Ronald D. Perrone, Kaleab Z. Abebe, Robert W. Schrier, Arlene B. Chapman, Vicente Torres, James Bost, Diana Kaya, Dana C. Miskulin, Theodore I. Steinman, William Braun, Franz T. Winklhofer, Marie C Hogan, Frederic Rahbari-Oskoui, Cass Kelleher, Amirali Masoumi, James Glockner, Neil J. Halin, Diego Martin, Erick Remer, Nayana PatelIvan Pedrosa, Louis H. Wetzel, Paul A. Thompson, J. Philip Miller, Catherine M. Meyers, K. Ty Bae

Research output: Contribution to journalArticle

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Abstract

Background and objectives: Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41% prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurements of LVM were performed using cardiac magnetic resonance (MR). Design, setting, participants, & measurements: Five hundred forty-three hypertensive patients with GFR >60 ml/min per 1.73 m2 underwent MR assessment of LVM at baseline. LVM was adjusted for body surface area and expressed as LVM index (LVMI; g/m2). Results: Baseline BP was 125.1 ± 14.5/79.3 ± 11.6 mmHg. Average duration of hypertension was 5.79 years. Prior use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was present in 59.5% of patients. The prevalence of LVH assessed using nonindexed LVM (g) was 3.9% (n = 21, eight men and 13 women) and 0.93% (n = 5, one man and four women) using LVMI (g/m2). In exploratory analyses, the prevalence of LVH using LVM indexed to H2.7, and the allometric index ppLVmassHW, ranged from 0.74% to 2.23% (n = 4 to 12). Multivariate regression showed significant direct associations of LVMI with systolic BP, serum creatinine, and albuminuria; significant inverse associations with LVMI were found with age and female gender. Conclusions: The prevalence of LVH in hypertensive ADPKD patients <50 years of age with short duration of hypertension, and prior use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is low. Early BP intervention in ADPKD may have decreased LVH and may potentially decrease cardiovascular mortality.

Original languageEnglish (US)
Pages (from-to)2508-2515
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2011

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Autosomal Dominant Polycystic Kidney
Left Ventricular Hypertrophy
Magnetic Resonance Spectroscopy
Angiotensin Receptor Antagonists
Hypertension
Angiotensin-Converting Enzyme Inhibitors
Albuminuria
Body Surface Area
Angiotensins
Intracranial Aneurysm
Creatinine
Cardiovascular Diseases
Kidney
Mortality
Serum

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease. / Perrone, Ronald D.; Abebe, Kaleab Z.; Schrier, Robert W.; Chapman, Arlene B.; Torres, Vicente; Bost, James; Kaya, Diana; Miskulin, Dana C.; Steinman, Theodore I.; Braun, William; Winklhofer, Franz T.; Hogan, Marie C; Rahbari-Oskoui, Frederic; Kelleher, Cass; Masoumi, Amirali; Glockner, James; Halin, Neil J.; Martin, Diego; Remer, Erick; Patel, Nayana; Pedrosa, Ivan; Wetzel, Louis H.; Thompson, Paul A.; Miller, J. Philip; Meyers, Catherine M.; Bae, K. Ty.

In: Clinical Journal of the American Society of Nephrology, Vol. 6, No. 10, 01.10.2011, p. 2508-2515.

Research output: Contribution to journalArticle

Perrone, RD, Abebe, KZ, Schrier, RW, Chapman, AB, Torres, V, Bost, J, Kaya, D, Miskulin, DC, Steinman, TI, Braun, W, Winklhofer, FT, Hogan, MC, Rahbari-Oskoui, F, Kelleher, C, Masoumi, A, Glockner, J, Halin, NJ, Martin, D, Remer, E, Patel, N, Pedrosa, I, Wetzel, LH, Thompson, PA, Miller, JP, Meyers, CM & Bae, KT 2011, 'Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease', Clinical Journal of the American Society of Nephrology, vol. 6, no. 10, pp. 2508-2515. https://doi.org/10.2215/CJN.04610511
Perrone, Ronald D. ; Abebe, Kaleab Z. ; Schrier, Robert W. ; Chapman, Arlene B. ; Torres, Vicente ; Bost, James ; Kaya, Diana ; Miskulin, Dana C. ; Steinman, Theodore I. ; Braun, William ; Winklhofer, Franz T. ; Hogan, Marie C ; Rahbari-Oskoui, Frederic ; Kelleher, Cass ; Masoumi, Amirali ; Glockner, James ; Halin, Neil J. ; Martin, Diego ; Remer, Erick ; Patel, Nayana ; Pedrosa, Ivan ; Wetzel, Louis H. ; Thompson, Paul A. ; Miller, J. Philip ; Meyers, Catherine M. ; Bae, K. Ty. / Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease. In: Clinical Journal of the American Society of Nephrology. 2011 ; Vol. 6, No. 10. pp. 2508-2515.
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abstract = "Background and objectives: Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41{\%} prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurements of LVM were performed using cardiac magnetic resonance (MR). Design, setting, participants, & measurements: Five hundred forty-three hypertensive patients with GFR >60 ml/min per 1.73 m2 underwent MR assessment of LVM at baseline. LVM was adjusted for body surface area and expressed as LVM index (LVMI; g/m2). Results: Baseline BP was 125.1 ± 14.5/79.3 ± 11.6 mmHg. Average duration of hypertension was 5.79 years. Prior use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was present in 59.5{\%} of patients. The prevalence of LVH assessed using nonindexed LVM (g) was 3.9{\%} (n = 21, eight men and 13 women) and 0.93{\%} (n = 5, one man and four women) using LVMI (g/m2). In exploratory analyses, the prevalence of LVH using LVM indexed to H2.7, and the allometric index ppLVmassHW, ranged from 0.74{\%} to 2.23{\%} (n = 4 to 12). Multivariate regression showed significant direct associations of LVMI with systolic BP, serum creatinine, and albuminuria; significant inverse associations with LVMI were found with age and female gender. Conclusions: The prevalence of LVH in hypertensive ADPKD patients <50 years of age with short duration of hypertension, and prior use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is low. Early BP intervention in ADPKD may have decreased LVH and may potentially decrease cardiovascular mortality.",
author = "Perrone, {Ronald D.} and Abebe, {Kaleab Z.} and Schrier, {Robert W.} and Chapman, {Arlene B.} and Vicente Torres and James Bost and Diana Kaya and Miskulin, {Dana C.} and Steinman, {Theodore I.} and William Braun and Winklhofer, {Franz T.} and Hogan, {Marie C} and Frederic Rahbari-Oskoui and Cass Kelleher and Amirali Masoumi and James Glockner and Halin, {Neil J.} and Diego Martin and Erick Remer and Nayana Patel and Ivan Pedrosa and Wetzel, {Louis H.} and Thompson, {Paul A.} and Miller, {J. Philip} and Meyers, {Catherine M.} and Bae, {K. Ty}",
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T1 - Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease

AU - Perrone, Ronald D.

AU - Abebe, Kaleab Z.

AU - Schrier, Robert W.

AU - Chapman, Arlene B.

AU - Torres, Vicente

AU - Bost, James

AU - Kaya, Diana

AU - Miskulin, Dana C.

AU - Steinman, Theodore I.

AU - Braun, William

AU - Winklhofer, Franz T.

AU - Hogan, Marie C

AU - Rahbari-Oskoui, Frederic

AU - Kelleher, Cass

AU - Masoumi, Amirali

AU - Glockner, James

AU - Halin, Neil J.

AU - Martin, Diego

AU - Remer, Erick

AU - Patel, Nayana

AU - Pedrosa, Ivan

AU - Wetzel, Louis H.

AU - Thompson, Paul A.

AU - Miller, J. Philip

AU - Meyers, Catherine M.

AU - Bae, K. Ty

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Background and objectives: Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41% prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurements of LVM were performed using cardiac magnetic resonance (MR). Design, setting, participants, & measurements: Five hundred forty-three hypertensive patients with GFR >60 ml/min per 1.73 m2 underwent MR assessment of LVM at baseline. LVM was adjusted for body surface area and expressed as LVM index (LVMI; g/m2). Results: Baseline BP was 125.1 ± 14.5/79.3 ± 11.6 mmHg. Average duration of hypertension was 5.79 years. Prior use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was present in 59.5% of patients. The prevalence of LVH assessed using nonindexed LVM (g) was 3.9% (n = 21, eight men and 13 women) and 0.93% (n = 5, one man and four women) using LVMI (g/m2). In exploratory analyses, the prevalence of LVH using LVM indexed to H2.7, and the allometric index ppLVmassHW, ranged from 0.74% to 2.23% (n = 4 to 12). Multivariate regression showed significant direct associations of LVMI with systolic BP, serum creatinine, and albuminuria; significant inverse associations with LVMI were found with age and female gender. Conclusions: The prevalence of LVH in hypertensive ADPKD patients <50 years of age with short duration of hypertension, and prior use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is low. Early BP intervention in ADPKD may have decreased LVH and may potentially decrease cardiovascular mortality.

AB - Background and objectives: Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41% prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurements of LVM were performed using cardiac magnetic resonance (MR). Design, setting, participants, & measurements: Five hundred forty-three hypertensive patients with GFR >60 ml/min per 1.73 m2 underwent MR assessment of LVM at baseline. LVM was adjusted for body surface area and expressed as LVM index (LVMI; g/m2). Results: Baseline BP was 125.1 ± 14.5/79.3 ± 11.6 mmHg. Average duration of hypertension was 5.79 years. Prior use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was present in 59.5% of patients. The prevalence of LVH assessed using nonindexed LVM (g) was 3.9% (n = 21, eight men and 13 women) and 0.93% (n = 5, one man and four women) using LVMI (g/m2). In exploratory analyses, the prevalence of LVH using LVM indexed to H2.7, and the allometric index ppLVmassHW, ranged from 0.74% to 2.23% (n = 4 to 12). Multivariate regression showed significant direct associations of LVMI with systolic BP, serum creatinine, and albuminuria; significant inverse associations with LVMI were found with age and female gender. Conclusions: The prevalence of LVH in hypertensive ADPKD patients <50 years of age with short duration of hypertension, and prior use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is low. Early BP intervention in ADPKD may have decreased LVH and may potentially decrease cardiovascular mortality.

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