Cardiac implantable electronic devices in adults with tetralogy of Fallot

Alexander C. Egbe, William R. Miranda, Malini Madhavan, Naser M. Ammash, Venkata R. Missula, Mohammed Al-Otaibi, Ayotola Fatola, Srikanth Kothapalli, Heidi M. Connolly

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background Tachyarrhythmias and bradyarrhythmias affect 20%-50% of adult patients with tetralogy of Fallot (TOF) and some of these patients will require cardiac implantable electronic devices (CIED) such as pacemaker and/or internal cardioverter defibrillator. Methods The Mayo Adult Congenital Heart Disease database was queried for patients with repaired TOF and history of CIED implantation, 1990-2017. The study objectives were: (1) determine the occurrence of device-related complications defined as lead failure, lead recall, device infection and lead thrombus; and (2) determine the occurrence and risk factors for defibrillator shock. Results There were 99 patients (age 46±14 years and 66 (66%) men) with CIED, and the CIEDs were 41 (41%) pacemakers and 73 (73%) defibrillators. Indication for defibrillator implantation was for primary prevention in 28 (38%) and secondary prevention in 45 (62%). Device-related complications occurred in 20 (20%) patients (lead failure 17, lead recall 4, device infection 12 and thrombus 3). Twenty-five per cent of all device infections occurred within 30 days from the time of device generator change. Annualised rates of appropriate and inappropriate shocks were 5.7% and 6.2%, respectively. The use of class III antiarrhythmic drug was protective against defibrillator shock. Conclusion The current study provides useful outcome data to aid patient counselling and clinical decision-making. Further studies are required to explore ways to decrease the risk of postprocedural infection after device generator change, and to determine which patients will benefit from empirical antiarrhythmic therapy as a strategy to decrease incidence of inappropriate defibrillator shock.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalHeart
Volume105
Issue number7
DOIs
StatePublished - Apr 1 2019

Keywords

  • tetralogy of Fallot

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Cardiac implantable electronic devices in adults with tetralogy of Fallot'. Together they form a unique fingerprint.

  • Cite this

    Egbe, A. C., Miranda, W. R., Madhavan, M., Ammash, N. M., Missula, V. R., Al-Otaibi, M., Fatola, A., Kothapalli, S., & Connolly, H. M. (2019). Cardiac implantable electronic devices in adults with tetralogy of Fallot. Heart, 105(7), 538-544. https://doi.org/10.1136/heartjnl-2018-314072