Cardiac hypertrophy determines digitalis action on intracellular Ca2+ in human myocardium

Jose R. Lopez, Nancy Linares, Peter A. Brady, Andre Terzic

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Ventricular hypertrophy alters transporters associated with digitalis action, but the outcome of digitalis treatment on intracellular cations in the hypertrophied human myocardium remains unknown. Using double-barreled Ca2+-selective microelectrodes, we simultaneously measured Ca2+ activity and membrane potential in myocardial samples from patients without and with ventricular hypertrophy, prior to and following exposure to strophanthidin, a prototype digitalis. We found that ventricular hypertrophy is associated with greater strophanthidin-induced increase in diastolic Ca2+ levels compared to that observed in the absence of hypertrophy. Furthermore, in hypertrophied myocardium the magnitude of the increase in Ca2+ induced by strophanthidin was inversely related to increase in myocardial mass. Thus, the extent of ventricular hypertrophy determines digitalis action on intracellular Ca2+ within the human myocardium.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalEuropean Journal of Pharmacology
Volume339
Issue number2-3
DOIs
StatePublished - Nov 27 1997

Keywords

  • Ca level
  • Diastolic
  • Ion-selective microelectrode
  • Ventricular mass

ASJC Scopus subject areas

  • Pharmacology

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