TY - JOUR
T1 - Cardiac Function and Diastolic Dysfunction in Behcet's Disease
T2 - A Systematic Review and Meta-Analysis
AU - Aslam, Fawad
AU - Bandeali, Salman J.
AU - Crowson, Cynthia
AU - Alam, Mahboob
N1 - Publisher Copyright:
© 2016 Fawad Aslam et al.
PY - 2016
Y1 - 2016
N2 - Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Our objective was to evaluate the existing literature to determine if cardiac dysfunction, particularly DD, was more prevalent in these patients. Methods. A systematic review and meta-analysis of the available studies analyzing the echocardiographic findings in BD was conducted using a random-effects model. Mean differences were used to calculate the effect sizes of the echocardiographic parameters of interest. Results. A total of 22 studies with 1624 subjects were included in the analysis. Patients with BD had statistically significantly larger mean left atrial dimension (0.08, p=0.0008), greater aortic diameter (0.16, p=0.02), significantly reduced ejection fraction (-1.08, p<0.0001), significantly prolonged mitral deceleration time (14.20, p<0.0001), lower E/A ratio (-0.24, p=0.05), and increased isovolumetric relaxation time (7.29, p<0.00001). Conclusion. DD is increased in patients with BD by the presence of several echocardiographic parameters favoring DD as compared to controls. The meta-analysis also identified that LA dimension is increased in BD patients. EF has also been found to be lower in BD patients. Aortic diameter was also increased in BD patients as compared to controls.
AB - Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Our objective was to evaluate the existing literature to determine if cardiac dysfunction, particularly DD, was more prevalent in these patients. Methods. A systematic review and meta-analysis of the available studies analyzing the echocardiographic findings in BD was conducted using a random-effects model. Mean differences were used to calculate the effect sizes of the echocardiographic parameters of interest. Results. A total of 22 studies with 1624 subjects were included in the analysis. Patients with BD had statistically significantly larger mean left atrial dimension (0.08, p=0.0008), greater aortic diameter (0.16, p=0.02), significantly reduced ejection fraction (-1.08, p<0.0001), significantly prolonged mitral deceleration time (14.20, p<0.0001), lower E/A ratio (-0.24, p=0.05), and increased isovolumetric relaxation time (7.29, p<0.00001). Conclusion. DD is increased in patients with BD by the presence of several echocardiographic parameters favoring DD as compared to controls. The meta-analysis also identified that LA dimension is increased in BD patients. EF has also been found to be lower in BD patients. Aortic diameter was also increased in BD patients as compared to controls.
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U2 - 10.1155/2016/9837184
DO - 10.1155/2016/9837184
M3 - Review article
AN - SCOPUS:84973154542
SN - 1687-9260
VL - 2016
JO - International Journal of Rheumatology
JF - International Journal of Rheumatology
M1 - 9837184
ER -