Cardiac channelopathies: It's in the genes

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

In 1995, Mark Keating and colleagues identified two genes responsible for congenital long QT syndrome, a cause of sudden cardiac death. Perturbations in the ion channels that orchestrate the beating heart were central to the disorder. This revelation provided a molecular model for the study of ventricular arrhythmias and enabled further dissection of the genetic defects underlying subtleties in the cardiac phenotype. Soon, these discoveries will be further translated to clinical medicine, with the expected release of one of the first comprehensive clinical genetic tests in cardiology.

Original languageEnglish (US)
Pages (from-to)463-464
Number of pages2
JournalNature Medicine
Volume10
Issue number5
DOIs
StatePublished - May 2004

Fingerprint

Channelopathies
Cardiology
Long QT Syndrome
Dissection
Molecular Models
Clinical Medicine
Sudden Cardiac Death
Ion Channels
Medicine
Cardiac Arrhythmias
Genes
Phenotype
Defects

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cardiac channelopathies : It's in the genes. / Ackerman, Michael John.

In: Nature Medicine, Vol. 10, No. 5, 05.2004, p. 463-464.

Research output: Contribution to journalArticle

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