Cardiac atrial natriuretic factor during evolution of congestive heart failure

M. A. Perrella, T. R. Schwab, B. O'Murchu, Margaret May Redfield, C. M. Wei, Brooks Sayre Edwards, John C Jr. Burnett

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Congestive heart failure (CHF) is a pathophysiological condition associated with increased plasma levels of atrial natriuretic factor (ANF), a peptide hormone of cardiac origin that participates in the homeostatic control of intravascular volume and vascular tone. Atrial myocytes serve as the principal source of ANF under physiological conditions, although recent studies have demonstrated that ventricular myocardium may also synthesize ANF in models of CHF associated with ventricular hypertrophy. The current study was designed to investigate the roles of atrial and ventricular myocardium to synthesize, store, and release ANF during the evolution of tachycardia- induced CHF in the dog. The present study demonstrates a persistent elevation of plasma ANF during the evolution of CHF. In acute CHF (3 h), plasma ANF increased independent of cardiac ANF synthesis. In chronic CHF (15 and 30 days), plasma ANF is maintained by an increase in atrial synthesis and release of the peptide, without recruitment of ventricular ANF synthesis. The present study demonstrates that in acute CHF the increase in plasma ANF is regulated by release of stored peptide, and in chronic CHF the persistent elevation of plasma ANF is maintained by an increase in atrial synthesis of ANF.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number4 31-4
StatePublished - 1992

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Atrial Natriuretic Factor
Heart Failure
Myocardium
Peptides
Peptide Hormones
Tachycardia
Muscle Cells
Hypertrophy
Blood Vessels
Dogs

Keywords

  • atrial peptides
  • myocardium
  • protein synthesis

ASJC Scopus subject areas

  • Physiology

Cite this

Cardiac atrial natriuretic factor during evolution of congestive heart failure. / Perrella, M. A.; Schwab, T. R.; O'Murchu, B.; Redfield, Margaret May; Wei, C. M.; Edwards, Brooks Sayre; Burnett, John C Jr.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 4 31-4, 1992.

Research output: Contribution to journalArticle

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AU - Wei, C. M.

AU - Edwards, Brooks Sayre

AU - Burnett, John C Jr.

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