Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs

R. W. Lee, S. Standaert, L. D. Lancaster, D. Buckley, S. Goldman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To determine the cardiac and peripheral circulatory responses to changes in afterload with angiotensin and vasopressin, we increased mean aortic pressure 25% and 50% above control in splenectomized and ganglion-blocked dogs. We compared these responses to similar mechanical increases in aortic pressure produced by partial balloon occlusion of the descending aorta. With 25% or 50% increases in aortic pressure, angiotensin, vasopressin, and balloon inflation produced no changes in heart rate, right atrial, and mean pulmonary artery pressures. At 25% increase in aortic pressure, cardiac output was maintained with angiotensin and balloon occlusion but decreased with vasopressin. At 50% increase in aortic pressure, cardiac output was maintained with only balloon occlusion and decreased with both angiotensin and vasopressin. Whenever cardiac output fell, central blood volume did not increase as afterload increased. These changes in preload can be explained by alterations in the venous circulation. Vasopressin did not alter venous compliance or unstressed vascular volume but increased resistance to venous return. Angiotensin also increased resistance to venous return but decreased venous compliance and did not change unstressed vascular volume. Balloon occlusion had no effects on these parameters. We conclude that: (a) angiotensin caused significant venoconstriction resulting in maintenance of cardiac output at 25% but not 50% increase in aortic pressure; (b) vasopressin increased the resistance to venous return without venoconstriction; this resulted in a fall in cardiac output even with a 25% increase in aortic pressure; and (c) the effects of the agents on the venous circulation were independent of the mechanical effects of a pressure increase in the arterial circulation.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalJournal of Clinical Investigation
Volume82
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

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Angiotensins
Vasopressins
Arterial Pressure
Balloon Occlusion
Dogs
Cardiac Output
Compliance
Blood Vessels
Pressure
Economic Inflation
Blood Volume
Thoracic Aorta
Ganglia
Pulmonary Artery
Heart Rate
Maintenance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, R. W., Standaert, S., Lancaster, L. D., Buckley, D., & Goldman, S. (1988). Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs. Journal of Clinical Investigation, 82(2), 413-419.

Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs. / Lee, R. W.; Standaert, S.; Lancaster, L. D.; Buckley, D.; Goldman, S.

In: Journal of Clinical Investigation, Vol. 82, No. 2, 01.01.1988, p. 413-419.

Research output: Contribution to journalArticle

Lee, RW, Standaert, S, Lancaster, LD, Buckley, D & Goldman, S 1988, 'Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs', Journal of Clinical Investigation, vol. 82, no. 2, pp. 413-419.
Lee RW, Standaert S, Lancaster LD, Buckley D, Goldman S. Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs. Journal of Clinical Investigation. 1988 Jan 1;82(2):413-419.
Lee, R. W. ; Standaert, S. ; Lancaster, L. D. ; Buckley, D. ; Goldman, S. / Cardiac and peripheral circulatory responses to angiotensin and vasopressin in dogs. In: Journal of Clinical Investigation. 1988 ; Vol. 82, No. 2. pp. 413-419.
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