Cardiac amyloidosis: Pathology, nomenclature, and typing

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Amyloidosis is an increasingly recognized cause of heart disease, caused by the deposition of misfolded protein within the heart. These proteins may deposit systemically and include the heart or deposit only within the heart muscle itself. In either case, cardiac symptoms may be the primary manifestation. The diagnosis is usually made by the pathologist identifying amyloid within a tissue sample. The diagnosis, however, does not end with such visual recognition of the presence of amyloid. Newer generation pharmacotherapeutic agents that are protein specific necessitate a closer evaluation to determine the type of protein being deposited and accurately conveying this to the treating clinician. Herein, the gross and histopathologic features of cardiac amyloidosis are reviewed along with a review of amyloid typing strategies (both direct and indirect) that may be employed in the diagnostic workup as well as the nomenclature standards for reporting.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalCardiovascular Pathology
Volume24
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Amyloidosis
Terminology
Amyloid
Pathology
Proteins
Heart Diseases
Myocardium

Keywords

  • Infiltrative cardiomyopathy
  • Proteomics
  • Restrictive cardiomyopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac amyloidosis : Pathology, nomenclature, and typing. / Maleszewski, Joseph.

In: Cardiovascular Pathology, Vol. 24, No. 6, 01.01.2015, p. 343-350.

Research output: Contribution to journalReview article

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