Cardiac Amyloidosis

Marinos C. Dalakas, Morie Gertz, L. J. Olson, W. D. Edwards, C. Y. li, Patricia Pellikka, David Holmes, A. J. Tajik, Robert A. Kyle

Research output: Contribution to journalLetter

Abstract

To the Editor: The effort by Olson et al. (Sept. 17 issue)1 to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type234 (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.

Original languageEnglish (US)
Pages (from-to)641-642
Number of pages2
JournalNew England Journal of Medicine
Volume318
Issue number10
DOIs
StatePublished - Mar 10 1988

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Amyloid Neuropathies
Amyloidosis
Amyloid
Amyloid Plaques
Immunoglobulins
Immune Sera
Immunohistochemistry
Staining and Labeling
Biopsy
Muscles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dalakas, M. C., Gertz, M., Olson, L. J., Edwards, W. D., li, C. Y., Pellikka, P., ... Kyle, R. A. (1988). Cardiac Amyloidosis. New England Journal of Medicine, 318(10), 641-642. https://doi.org/10.1056/NEJM198803103181015

Cardiac Amyloidosis. / Dalakas, Marinos C.; Gertz, Morie; Olson, L. J.; Edwards, W. D.; li, C. Y.; Pellikka, Patricia; Holmes, David; Tajik, A. J.; Kyle, Robert A.

In: New England Journal of Medicine, Vol. 318, No. 10, 10.03.1988, p. 641-642.

Research output: Contribution to journalLetter

Dalakas, MC, Gertz, M, Olson, LJ, Edwards, WD, li, CY, Pellikka, P, Holmes, D, Tajik, AJ & Kyle, RA 1988, 'Cardiac Amyloidosis', New England Journal of Medicine, vol. 318, no. 10, pp. 641-642. https://doi.org/10.1056/NEJM198803103181015
Dalakas MC, Gertz M, Olson LJ, Edwards WD, li CY, Pellikka P et al. Cardiac Amyloidosis. New England Journal of Medicine. 1988 Mar 10;318(10):641-642. https://doi.org/10.1056/NEJM198803103181015
Dalakas, Marinos C. ; Gertz, Morie ; Olson, L. J. ; Edwards, W. D. ; li, C. Y. ; Pellikka, Patricia ; Holmes, David ; Tajik, A. J. ; Kyle, Robert A. / Cardiac Amyloidosis. In: New England Journal of Medicine. 1988 ; Vol. 318, No. 10. pp. 641-642.
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