To the Editor: The effort by Olson et al. (Sept. 17 issue)1 to characterize deposits of cardiac amyloid is identical to our work on the characterization of amyloid deposits in muscle and nerve biopsy specimens from patients with amyloid polyneuropathy of the “sporadic” type234 (the nonfamilial, nonsecretory immunoglobulin-derived amyloid). The study is also relevant to ours because in amyloid polyneuropathy the heart is involved by amyloid. I have concerns, however, about the specificity of the staining with the antiserums used. After 10 years of experience with the immunohistochemistry of amyloid, we have found that immunostaining is not as simple as.
ASJC Scopus subject areas