"Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis

S. Michael Gharacholou, Joseph J. Maleszewski, Barry A. Borlaug, Fernando G. Cosio, Joseph A. Dearani, Sudhir S. Kushwaha, Naser M. Ammash

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We present a case of a patient with end-stage renal disease and nephrogenic fibrosing dermopathy (NFD) whose echocardiogram demonstrated rare tricuspid valve abnormality with malcoaptation due to tethering and restricted motion of the leaflets causing severe tricuspid regurgitation. The cardiac abnormalities developed 3 years after her initial diagnosis of NFD was made by skin biopsy. The echocardiographic appearance of the tricuspid valve resembled that seen in patients with carcinoid heart disease; however, an evaluation for carcinoid tumor in our patient was negative. Myocardial biopsy performed at the time of right heart catheterization demonstrated trace gadolinium within the lysosomes of one cardiac fibroblast. This report is the first to describe the association between nephrogenic systemic fibrosis and severe valvular heart disease requiring valve replacement.

Original languageEnglish (US)
Pages (from-to)E46-E49
JournalEchocardiography
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • nephrogenic systemic fibrosis
  • tricuspid regurgitation
  • valve replacement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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