"Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis

Shahyar Gharacholou, Joseph Maleszewski, Barry A Borlaug, Fernando G Cosio, Joseph A. Dearani, Sudhir S. Kushwaha, Naser M. Ammash

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We present a case of a patient with end-stage renal disease and nephrogenic fibrosing dermopathy (NFD) whose echocardiogram demonstrated rare tricuspid valve abnormality with malcoaptation due to tethering and restricted motion of the leaflets causing severe tricuspid regurgitation. The cardiac abnormalities developed 3 years after her initial diagnosis of NFD was made by skin biopsy. The echocardiographic appearance of the tricuspid valve resembled that seen in patients with carcinoid heart disease; however, an evaluation for carcinoid tumor in our patient was negative. Myocardial biopsy performed at the time of right heart catheterization demonstrated trace gadolinium within the lysosomes of one cardiac fibroblast. This report is the first to describe the association between nephrogenic systemic fibrosis and severe valvular heart disease requiring valve replacement.

Original languageEnglish (US)
JournalEchocardiography
Volume28
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Nephrogenic Fibrosing Dermopathy
Carcinoid Tumor
Tricuspid Valve
Carcinoid Heart Disease
Biopsy
Tricuspid Valve Insufficiency
Heart Valve Diseases
Gadolinium
Cardiac Catheterization
Lysosomes
Chronic Kidney Failure
Fibroblasts
Skin

Keywords

  • nephrogenic systemic fibrosis
  • tricuspid regurgitation
  • valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

"Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. / Gharacholou, Shahyar; Maleszewski, Joseph; Borlaug, Barry A; Cosio, Fernando G; Dearani, Joseph A.; Kushwaha, Sudhir S.; Ammash, Naser M.

In: Echocardiography, Vol. 28, No. 3, 03.2011.

Research output: Contribution to journalArticle

Gharacholou, Shahyar ; Maleszewski, Joseph ; Borlaug, Barry A ; Cosio, Fernando G ; Dearani, Joseph A. ; Kushwaha, Sudhir S. ; Ammash, Naser M. / "Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. In: Echocardiography. 2011 ; Vol. 28, No. 3.
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