Carcinoid Heart Disease in Patients Without Hepatic Metastases

Alain M. Bernheim, Heidi M. Connolly, Patricia Pellikka

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Most carcinoid tumors originate in the gut. Carcinoid heart disease typically occurs when tumor progression results in the formation of hepatic metastases, which allow vasoactive substances to reach the heart without being metabolized in the liver. Except for patients with primary ovarian carcinoid tumors, the occurrence of carcinoid heart disease without hepatic metastases has been reported only anecdotally. From a retrospective analysis of 265 patients, 4 patients were identified who developed carcinoid heart disease in the absence of liver metastases or primary tumors located in the ovaries. All 4 patients had metastases to the retroperitoneal lymph nodes and had carcinoid syndrome. The reasons for referral to cardiac evaluation by transthoracic echocardiography were findings on auscultation in 3 patients and exertional dyspnea in 1 patient. In conclusion, cardiac symptoms or findings on auscultation should prompt further evaluation by transthoracic echocardiography in these patients, although the classic prerequisites for development of carcinoid heart disease are lacking.

Original languageEnglish (US)
Pages (from-to)292-294
Number of pages3
JournalAmerican Journal of Cardiology
Volume99
Issue number2
DOIs
StatePublished - Jan 15 2007

Fingerprint

Carcinoid Heart Disease
Neoplasm Metastasis
Liver
Carcinoid Tumor
Auscultation
Echocardiography
Dyspnea
Ovary
Neoplasms
Referral and Consultation
Lymph Nodes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Carcinoid Heart Disease in Patients Without Hepatic Metastases. / Bernheim, Alain M.; Connolly, Heidi M.; Pellikka, Patricia.

In: American Journal of Cardiology, Vol. 99, No. 2, 15.01.2007, p. 292-294.

Research output: Contribution to journalArticle

Bernheim, Alain M. ; Connolly, Heidi M. ; Pellikka, Patricia. / Carcinoid Heart Disease in Patients Without Hepatic Metastases. In: American Journal of Cardiology. 2007 ; Vol. 99, No. 2. pp. 292-294.
@article{b4749eea4b3d41afaabea57420885d1c,
title = "Carcinoid Heart Disease in Patients Without Hepatic Metastases",
abstract = "Most carcinoid tumors originate in the gut. Carcinoid heart disease typically occurs when tumor progression results in the formation of hepatic metastases, which allow vasoactive substances to reach the heart without being metabolized in the liver. Except for patients with primary ovarian carcinoid tumors, the occurrence of carcinoid heart disease without hepatic metastases has been reported only anecdotally. From a retrospective analysis of 265 patients, 4 patients were identified who developed carcinoid heart disease in the absence of liver metastases or primary tumors located in the ovaries. All 4 patients had metastases to the retroperitoneal lymph nodes and had carcinoid syndrome. The reasons for referral to cardiac evaluation by transthoracic echocardiography were findings on auscultation in 3 patients and exertional dyspnea in 1 patient. In conclusion, cardiac symptoms or findings on auscultation should prompt further evaluation by transthoracic echocardiography in these patients, although the classic prerequisites for development of carcinoid heart disease are lacking.",
author = "Bernheim, {Alain M.} and Connolly, {Heidi M.} and Patricia Pellikka",
year = "2007",
month = "1",
day = "15",
doi = "10.1016/j.amjcard.2006.07.092",
language = "English (US)",
volume = "99",
pages = "292--294",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Carcinoid Heart Disease in Patients Without Hepatic Metastases

AU - Bernheim, Alain M.

AU - Connolly, Heidi M.

AU - Pellikka, Patricia

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Most carcinoid tumors originate in the gut. Carcinoid heart disease typically occurs when tumor progression results in the formation of hepatic metastases, which allow vasoactive substances to reach the heart without being metabolized in the liver. Except for patients with primary ovarian carcinoid tumors, the occurrence of carcinoid heart disease without hepatic metastases has been reported only anecdotally. From a retrospective analysis of 265 patients, 4 patients were identified who developed carcinoid heart disease in the absence of liver metastases or primary tumors located in the ovaries. All 4 patients had metastases to the retroperitoneal lymph nodes and had carcinoid syndrome. The reasons for referral to cardiac evaluation by transthoracic echocardiography were findings on auscultation in 3 patients and exertional dyspnea in 1 patient. In conclusion, cardiac symptoms or findings on auscultation should prompt further evaluation by transthoracic echocardiography in these patients, although the classic prerequisites for development of carcinoid heart disease are lacking.

AB - Most carcinoid tumors originate in the gut. Carcinoid heart disease typically occurs when tumor progression results in the formation of hepatic metastases, which allow vasoactive substances to reach the heart without being metabolized in the liver. Except for patients with primary ovarian carcinoid tumors, the occurrence of carcinoid heart disease without hepatic metastases has been reported only anecdotally. From a retrospective analysis of 265 patients, 4 patients were identified who developed carcinoid heart disease in the absence of liver metastases or primary tumors located in the ovaries. All 4 patients had metastases to the retroperitoneal lymph nodes and had carcinoid syndrome. The reasons for referral to cardiac evaluation by transthoracic echocardiography were findings on auscultation in 3 patients and exertional dyspnea in 1 patient. In conclusion, cardiac symptoms or findings on auscultation should prompt further evaluation by transthoracic echocardiography in these patients, although the classic prerequisites for development of carcinoid heart disease are lacking.

UR - http://www.scopus.com/inward/record.url?scp=33846105546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846105546&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2006.07.092

DO - 10.1016/j.amjcard.2006.07.092

M3 - Article

VL - 99

SP - 292

EP - 294

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 2

ER -