Carcinogenesis of Pancreatic Ductal Adenocarcinoma

Peter Storz, Howard C. Crawford

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop from duct-like cells through a multistep carcinogenesis process, from low-grade dysplastic lesions to carcinoma in situ and eventually to metastatic disease. This process involves gradual acquisition of mutations in oncogenes and tumor suppressor genes, as well as changes in the pancreatic environment from a pro-inflammatory microenvironment that favors the development of early lesions, to a desmoplastic tumor microenvironment that is highly fibrotic and immune suppressive. This review discusses our current understanding of how PDA originates.

Original languageEnglish (US)
Pages (from-to)2072-2081
Number of pages10
JournalGastroenterology
Volume158
Issue number8
DOIs
StatePublished - Jun 2020

Keywords

  • Carcinogenesis
  • Desmoplastic Reaction
  • Microenvironment
  • Pancreatic Ductal Adenocarcinoma
  • Pancreatic Intraepithelial Neoplasia

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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