Carbon nanofiber electrode for neurochemical monitoring

David A. Zhang, Emily Rand, Michael Marsh, Russell J. Andrews, Kendall H Lee, M. Meyyappan, Jessica E. Koehne

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The ability to rapidly detect neurotransmitter release has broad implications in the study of a variety of neurodegenerative diseases. Electrochemical detection methods using carbon nanofiber nanoelectrodes integrated into the Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) offer many important advantages including biocompatibility, selectivity, sensitivity, and rapid adsorption kinetics. Carbon nanofiber nanoelectrodes exhibit greater selectivity and sensitivity in the electrochemical detection of neurotransmitters compared to macroelectrodes and are able to resolve a ternary mixture of dopamine (DA), serotonin (5-HT), and ascorbic acid as well as to detect individual neurotransmitters in concentrations as low as 50 nM for DA and 100 nM for 5-HT using differential pulse voltammetry. Adsorption kinetics studies and isopropyl alcohol treatments modeled on previous studies on carbon fiber microelectrodes were conducted to investigate the analogous properties on carbon nanofiber electrodes using fast-scan cyclic voltammetry with WINCS and showed analogous results in carbon nanofiber electrodes compared with carbon fiber microelectrodes.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalMolecular Neurobiology
Volume48
Issue number2
DOIs
StatePublished - Oct 2013

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Nanofibers
Neurotransmitter Agents
Electrodes
Carbon
Serotonin
Microelectrodes
Adsorption
Dopamine
2-Propanol
Neurodegenerative Diseases
Ascorbic Acid

Keywords

  • Biosensor
  • Carbon nanofiber
  • Nanoelectrode
  • Neurotransmitter

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Zhang, D. A., Rand, E., Marsh, M., Andrews, R. J., Lee, K. H., Meyyappan, M., & Koehne, J. E. (2013). Carbon nanofiber electrode for neurochemical monitoring. Molecular Neurobiology, 48(2), 380-385. https://doi.org/10.1007/s12035-013-8531-6

Carbon nanofiber electrode for neurochemical monitoring. / Zhang, David A.; Rand, Emily; Marsh, Michael; Andrews, Russell J.; Lee, Kendall H; Meyyappan, M.; Koehne, Jessica E.

In: Molecular Neurobiology, Vol. 48, No. 2, 10.2013, p. 380-385.

Research output: Contribution to journalArticle

Zhang, DA, Rand, E, Marsh, M, Andrews, RJ, Lee, KH, Meyyappan, M & Koehne, JE 2013, 'Carbon nanofiber electrode for neurochemical monitoring', Molecular Neurobiology, vol. 48, no. 2, pp. 380-385. https://doi.org/10.1007/s12035-013-8531-6
Zhang DA, Rand E, Marsh M, Andrews RJ, Lee KH, Meyyappan M et al. Carbon nanofiber electrode for neurochemical monitoring. Molecular Neurobiology. 2013 Oct;48(2):380-385. https://doi.org/10.1007/s12035-013-8531-6
Zhang, David A. ; Rand, Emily ; Marsh, Michael ; Andrews, Russell J. ; Lee, Kendall H ; Meyyappan, M. ; Koehne, Jessica E. / Carbon nanofiber electrode for neurochemical monitoring. In: Molecular Neurobiology. 2013 ; Vol. 48, No. 2. pp. 380-385.
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