Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract

J. H. Szurszewski, Gianrico Farrugia

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In all mammalian species examined to date, there is a 10 mV or more gradient in resting membrane potential across the wall of the gastric antrum, small intestine and colon, and an even larger gradient along the long axis of the stomach. These voltage gradients, which may be considered biological rheostats, are central to the ability of circular smooth muscle to vary the strength of contraction from weak to propulsive and occluding. In this short review, we consider recent data that support the hypothesis that carbon monoxide generated in interstitial cells of Cajal is a hyperpolarizing factor for circular smooth muscle and the root of the essential voltage gradients.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalNeurogastroenterology and Motility
Volume16
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 2004

Fingerprint

Carbon Monoxide
Smooth Muscle
Gastrointestinal Tract
Interstitial Cells of Cajal
Pyloric Antrum
Membrane Potentials
Small Intestine
Stomach
Colon

Keywords

  • Carbon monoxide
  • Circular smooth muscle
  • Haem oxygenase
  • Interstitial cells of Cajal
  • Voltage gradients

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract. / Szurszewski, J. H.; Farrugia, Gianrico.

In: Neurogastroenterology and Motility, Vol. 16, No. SUPPL. 1, 04.2004, p. 81-85.

Research output: Contribution to journalArticle

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