CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement

Choon Ta Ng, Hilda M. Gonzalez Bonilla, Ian Chang, M. Tun Aung, Jennifer J. Gile, Naveen L. Pereira, Jose C. Villasboas Bisneto, Patrick B. Johnston, Hector R. Villarraga, Martin G. Rodriguez-Porcel, Grace Lin, Yi Lin, Joerg Herrmann

Research output: Contribution to journalArticlepeer-review

Abstract

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies. However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life-threatening complications such as ventricular rupture, cardiac tamponade, and circulatory failure. We present a case series of patients with lymphoma and cardiomyopathy or cardiac metastasis managed with chimeric antigen receptor T-cell therapy. (Level of Difficulty: Advanced.)

Original languageEnglish (US)
Article number101840
JournalJACC: Case Reports
Volume15
DOIs
StatePublished - Jun 7 2023

Keywords

  • CAR-T
  • cardiac
  • cardio-oncology
  • cardiomyopathy
  • lymphoma
  • metastasis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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