CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

Mohamad Mohty; Remy Dulery; Jordan Gauthier; Florent Malard; Eolia Brissot; Mahmoud Aljurf; Ali Bazarbachi; Christian Chabanon; Mohamed A. Kharfan-Dabaja; Bipin N. Savani; He Huang; Saad S. Kenderian; Miguel Angel Perales; Ibrahim Yakoub-Agha; Arnon Nagler

doi:10.1038/s41409-020-0892-7

CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

Mohamad Mohty, Remy Dulery, Jordan Gauthier, Florent Malard, Eolia Brissot, Mahmoud Aljurf, Ali Bazarbachi, Christian Chabanon, Mohamed A. Kharfan-Dabaja, Bipin N. Savani, He Huang, Saad S. Kenderian, Miguel Angel Perales, Ibrahim Yakoub-Agha, Arnon Nagler

Hematology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.

Original language	English (US)
Pages (from-to)	1525-1532
Number of pages	8
Journal	Bone Marrow Transplantation
Volume	55
Issue number	8
DOIs	https://doi.org/10.1038/s41409-020-0892-7
State	Published - Aug 1 2020

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/s41409-020-0892-7

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Mohty, M., Dulery, R., Gauthier, J., Malard, F., Brissot, E., Aljurf, M., Bazarbachi, A., Chabanon, C., Kharfan-Dabaja, M. A., Savani, B. N., Huang, H., Kenderian, S. S., Perales, M. A., Yakoub-Agha, I., & Nagler, A. (2020). CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview. Bone Marrow Transplantation, 55(8), 1525-1532. https://doi.org/10.1038/s41409-020-0892-7

Mohty, M, Dulery, R, Gauthier, J, Malard, F, Brissot, E, Aljurf, M, Bazarbachi, A, Chabanon, C, Kharfan-Dabaja, MA, Savani, BN, Huang, H, Kenderian, SS, Perales, MA, Yakoub-Agha, I & Nagler, A 2020, 'CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview', Bone Marrow Transplantation, vol. 55, no. 8, pp. 1525-1532. https://doi.org/10.1038/s41409-020-0892-7

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abstract = "The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.",

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AU - Brissot, Eolia

AU - Aljurf, Mahmoud

AU - Bazarbachi, Ali

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CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

Abstract

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