Candida albicans osteomyelitis in a liver transplant recipient: A case report and review of the literature

Sudhakar Jonnalagadda, Manjakkollai P. Veerabagu, Jorge Rakela, Shimon Kusne, Parmjeet Randhawa, Mordechai Rabinovitz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A 51-year-old man developed fever and back pain 2 months after orthotopic liver transplantation for end-stage liver disease secondary to chronic hepatitis C infection. CT scan demonstrated destructive lesions in T12 suggestive of osteomyelitis. Aspiration biopsy of the vertebra revealed granulomatous inflammation and yeast forms; culture yielded Candida albicans. The patient improved with intravenous amphotericin B and 5-fluorocytosine and did not require surgical intervention. Candida osteomyelitis is a rare condition and to our knowledge it has not been reported before in liver transplant recipients. Awareness of this potential complication may shorten the delay in making the definitive diagnosis, which in turn may increase the likelihood of a response without sequela.

Original languageEnglish (US)
Pages (from-to)1182-1184
Number of pages3
JournalTransplantation
Volume62
Issue number8
DOIs
StatePublished - Oct 27 1996
Externally publishedYes

Fingerprint

Osteomyelitis
Candida albicans
Flucytosine
End Stage Liver Disease
Liver
Needle Biopsy
Amphotericin B
Chronic Hepatitis C
Back Pain
Candida
Liver Transplantation
Spine
Fever
Yeasts
Inflammation
Infection
Transplant Recipients

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Candida albicans osteomyelitis in a liver transplant recipient : A case report and review of the literature. / Jonnalagadda, Sudhakar; Veerabagu, Manjakkollai P.; Rakela, Jorge; Kusne, Shimon; Randhawa, Parmjeet; Rabinovitz, Mordechai.

In: Transplantation, Vol. 62, No. 8, 27.10.1996, p. 1182-1184.

Research output: Contribution to journalArticle

Jonnalagadda, Sudhakar ; Veerabagu, Manjakkollai P. ; Rakela, Jorge ; Kusne, Shimon ; Randhawa, Parmjeet ; Rabinovitz, Mordechai. / Candida albicans osteomyelitis in a liver transplant recipient : A case report and review of the literature. In: Transplantation. 1996 ; Vol. 62, No. 8. pp. 1182-1184.
@article{24151b79ecc54ba39a7d1d36dadfff10,
title = "Candida albicans osteomyelitis in a liver transplant recipient: A case report and review of the literature",
abstract = "A 51-year-old man developed fever and back pain 2 months after orthotopic liver transplantation for end-stage liver disease secondary to chronic hepatitis C infection. CT scan demonstrated destructive lesions in T12 suggestive of osteomyelitis. Aspiration biopsy of the vertebra revealed granulomatous inflammation and yeast forms; culture yielded Candida albicans. The patient improved with intravenous amphotericin B and 5-fluorocytosine and did not require surgical intervention. Candida osteomyelitis is a rare condition and to our knowledge it has not been reported before in liver transplant recipients. Awareness of this potential complication may shorten the delay in making the definitive diagnosis, which in turn may increase the likelihood of a response without sequela.",
author = "Sudhakar Jonnalagadda and Veerabagu, {Manjakkollai P.} and Jorge Rakela and Shimon Kusne and Parmjeet Randhawa and Mordechai Rabinovitz",
year = "1996",
month = "10",
day = "27",
doi = "10.1097/00007890-199610270-00028",
language = "English (US)",
volume = "62",
pages = "1182--1184",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Candida albicans osteomyelitis in a liver transplant recipient

T2 - A case report and review of the literature

AU - Jonnalagadda, Sudhakar

AU - Veerabagu, Manjakkollai P.

AU - Rakela, Jorge

AU - Kusne, Shimon

AU - Randhawa, Parmjeet

AU - Rabinovitz, Mordechai

PY - 1996/10/27

Y1 - 1996/10/27

N2 - A 51-year-old man developed fever and back pain 2 months after orthotopic liver transplantation for end-stage liver disease secondary to chronic hepatitis C infection. CT scan demonstrated destructive lesions in T12 suggestive of osteomyelitis. Aspiration biopsy of the vertebra revealed granulomatous inflammation and yeast forms; culture yielded Candida albicans. The patient improved with intravenous amphotericin B and 5-fluorocytosine and did not require surgical intervention. Candida osteomyelitis is a rare condition and to our knowledge it has not been reported before in liver transplant recipients. Awareness of this potential complication may shorten the delay in making the definitive diagnosis, which in turn may increase the likelihood of a response without sequela.

AB - A 51-year-old man developed fever and back pain 2 months after orthotopic liver transplantation for end-stage liver disease secondary to chronic hepatitis C infection. CT scan demonstrated destructive lesions in T12 suggestive of osteomyelitis. Aspiration biopsy of the vertebra revealed granulomatous inflammation and yeast forms; culture yielded Candida albicans. The patient improved with intravenous amphotericin B and 5-fluorocytosine and did not require surgical intervention. Candida osteomyelitis is a rare condition and to our knowledge it has not been reported before in liver transplant recipients. Awareness of this potential complication may shorten the delay in making the definitive diagnosis, which in turn may increase the likelihood of a response without sequela.

UR - http://www.scopus.com/inward/record.url?scp=0029972229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029972229&partnerID=8YFLogxK

U2 - 10.1097/00007890-199610270-00028

DO - 10.1097/00007890-199610270-00028

M3 - Article

C2 - 8900324

AN - SCOPUS:0029972229

VL - 62

SP - 1182

EP - 1184

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 8

ER -