TY - JOUR
T1 - Cancer pharmacogenomics and pharmacoepidemiology
T2 - Setting a research agenda to accelerate translation
AU - Freedman, Andrew N.
AU - Sansbury, Leah B.
AU - Figg, William D.
AU - Potosky, Arnold L.
AU - Weiss Smith, Sheila R.
AU - Khoury, Muin J.
AU - Nelson, Stefanie A.
AU - Weinshilboum, Richard M.
AU - Ratain, Mark J.
AU - McLeod, Howard L.
AU - Epstein, Robert S.
AU - Ginsburg, Geoffrey S.
AU - Schilsky, Richard L.
AU - Liu, Geoffrey
AU - Flockhart, David A.
AU - Ulrich, Cornelia M.
AU - Davis, Robert L.
AU - Lesko, Lawrence J.
AU - Zineh, Issam
AU - Randhawa, Gurvaneet
AU - Ambrosone, Christine B.
AU - Relling, Mary V.
AU - Rothman, Nat
AU - Xie, Heng
AU - Spitz, Margaret R.
AU - Ballard-Barbash, Rachel
AU - Doroshow, James H.
AU - Minasian, Lori M.
PY - 2010/11
Y1 - 2010/11
N2 - Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation" on July 21, 2009, in Bethesda, MD. In this commentary, we summarize and discuss five science-based recommendations and four infrastructure-based recommendations that were identified as a result of discussions held during this workshop. Key recommendations include 1) supporting the routine collection of germline and tumor biospecimens in NCI-sponsored clinical trials and in some observational and population-based studies; 2) incorporating pharmacogenomic markers into clinical trials; 3) addressing the ethical, legal, social, and biospecimen- and data-sharing implications of pharmacogenomic and pharmacoepidemiologic research; and 4) establishing partnerships across NCI, with other federal agencies, and with industry. Together, these recommendations will facilitate the discovery and validation of clinical, sociodemographic, lifestyle, and genomic markers related to cancer treatment response and adverse events, and they will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice.
AB - Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation" on July 21, 2009, in Bethesda, MD. In this commentary, we summarize and discuss five science-based recommendations and four infrastructure-based recommendations that were identified as a result of discussions held during this workshop. Key recommendations include 1) supporting the routine collection of germline and tumor biospecimens in NCI-sponsored clinical trials and in some observational and population-based studies; 2) incorporating pharmacogenomic markers into clinical trials; 3) addressing the ethical, legal, social, and biospecimen- and data-sharing implications of pharmacogenomic and pharmacoepidemiologic research; and 4) establishing partnerships across NCI, with other federal agencies, and with industry. Together, these recommendations will facilitate the discovery and validation of clinical, sociodemographic, lifestyle, and genomic markers related to cancer treatment response and adverse events, and they will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice.
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U2 - 10.1093/jnci/djq390
DO - 10.1093/jnci/djq390
M3 - Comment/debate
C2 - 20944079
AN - SCOPUS:78649371176
SN - 0027-8874
VL - 102
SP - 1698
EP - 1705
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 22
ER -