Cancer immunotherapy in patients with preexisting inflammatory arthritis

Uma Thanarajasingam, Noha Abdel-Wahab

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter focuses on patients with a preexisting inflammatory arthritis subsequently treated by immune checkpoint inhibitor (ICI) therapy for malignancy. We summarize the available epidemiologic and pathologic studies involving this subgroup of patients. An illustrative case of a patient with preexisting rheumatoid arthritis exposed to ICI for melanoma and followed longitudinally is presented in detail to highlight the clinical course and management challenges faced when caring for these patients.

Original languageEnglish (US)
Title of host publicationRheumatic Diseases and Syndromes Induced by Cancer Immunotherapy
Subtitle of host publicationA Handbook for Diagnosis and Management
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783030568245
ISBN (Print)9783030568238
StatePublished - Feb 16 2021


  • Immune checkpoint inhibitors
  • Immune-related adverse events
  • Inflammatory arthritis
  • Preexisting rheumatic diseases

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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