Cancer health effects of pesticides: Systematic review

K. L. Bassil, Catherine Vakil, M. Sanborn, D. C. Cole, Judith S Kaur, K. J. Kerr

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

OBJECTIVE: To review literature documenting associations between pesticide use and cancer. DATA SOURCES: We searched MEDLINE, PreMedline, CancerLit, and LILACS to find studies published between 1992 and 2003 on non-Hodgkin lymphoma, leukemia, and 8 solid-tumour cancers: brain, breast, kidney, lung, ovarian, pancreatic, prostate, and stomach cancer. STUDY SELECTION: Each title and abstract was assessed for relevance; disagreements among reviewers were resolved by consensus. Studies were assessed by a team of 2 trained reviewers and rated based on methodologic quality according to a 5-page assessment tool and a global assessment scale. Studies rated below a global score of 4 out of 7 were excluded. SYNTHESIS: Most studies on non-Hodgkin lymphoma and leukemia showed positive associations with pesticide exposure. Some showed dose-response relationships, and a few were able to identify specific pesticides. Children's and pregnant women's exposure to pesticides was positively associated with the cancers studied in some studies, as was parents' exposure to pesticides at work. Many studies showed positive associations between pesticide exposure and solid tumours. The most consistent associations were found for brain and prostate cancer. An association was also found between kidney cancer in children and their parents' exposure to pesticides at work. These associations were most consistent for high and prolonged exposures. Specific weaknesses and inherent limitations in epidemiologic studies were noted, particularly around ascertaining whether and how much exposure had taken place. CONCLUSION: Our findings support attempts to reduce exposure to pesticides. Reductions are likely best achieved through decreasing pesticide use for cosmetic (non-commercial) purposes (where children might be exposed) and on the job.

Original languageEnglish (US)
Pages (from-to)1705-1711
Number of pages7
JournalCanadian Family Physician
Volume53
Issue number10
StatePublished - Oct 2007

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Pesticides
Health
Neoplasms
Brain Neoplasms
Kidney Neoplasms
Non-Hodgkin's Lymphoma
Prostatic Neoplasms
Leukemia
Parents
Breast Neoplasms
Pancreatic Neoplasms
MEDLINE
Cosmetics
Ovarian Neoplasms
Stomach Neoplasms
Pregnant Women
Epidemiologic Studies
Lung Neoplasms
Consensus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bassil, K. L., Vakil, C., Sanborn, M., Cole, D. C., Kaur, J. S., & Kerr, K. J. (2007). Cancer health effects of pesticides: Systematic review. Canadian Family Physician, 53(10), 1705-1711.

Cancer health effects of pesticides : Systematic review. / Bassil, K. L.; Vakil, Catherine; Sanborn, M.; Cole, D. C.; Kaur, Judith S; Kerr, K. J.

In: Canadian Family Physician, Vol. 53, No. 10, 10.2007, p. 1705-1711.

Research output: Contribution to journalArticle

Bassil, KL, Vakil, C, Sanborn, M, Cole, DC, Kaur, JS & Kerr, KJ 2007, 'Cancer health effects of pesticides: Systematic review', Canadian Family Physician, vol. 53, no. 10, pp. 1705-1711.
Bassil KL, Vakil C, Sanborn M, Cole DC, Kaur JS, Kerr KJ. Cancer health effects of pesticides: Systematic review. Canadian Family Physician. 2007 Oct;53(10):1705-1711.
Bassil, K. L. ; Vakil, Catherine ; Sanborn, M. ; Cole, D. C. ; Kaur, Judith S ; Kerr, K. J. / Cancer health effects of pesticides : Systematic review. In: Canadian Family Physician. 2007 ; Vol. 53, No. 10. pp. 1705-1711.
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