Cancer control problems in the lynch syndromes

H. T. Lynch, Thomas Christopher Smyrk, S. J. Lanspa, J. X. Jenkins, J. Cavalieri, J. F. Lynch

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The Lynch syndromes account for about 4 to 6 percent of the total colorectal cancer (CRC) burden. Despite more than two decades of documentation in the literature, many physicians fail to recognize the clinical features of these syndromes. The lack of premonitory physical stigmata, coupled with the absence of a biomarker of cancer susceptibility, mandates full reliance on a well-orchestrated family history for diagnosis. These deficiencies impede cancer control. Even if the diagnosis is made, proper surveillance and management measures that are responsive to the Lynch syndromes' natural history may fail to be implemented. We describe CRC occurrences in patients from four extended Lynch syndrome kindreds. Failures in cancer control were attributable to poor patient compliance and/or to limited physician knowledge about the natural history and surveillance recommendations for the Lynch syndromes. Physicians need to more effectively educate their high-risk patients about the significance of genetic risk, the natural history of CRC, and the appropriate surveillance strategies in the Lynch syndromes.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalDiseases of the Colon and Rectum
Volume36
Issue number3
StatePublished - 1993
Externally publishedYes

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Hereditary Nonpolyposis Colorectal Neoplasms
Colorectal Neoplasms
Neoplasms
Natural History
Physicians
Christianity
Patient Compliance
Tumor Biomarkers
Documentation

Keywords

  • Cancer Control
  • Cancer genetic diagnosis
  • Lynch syndromes
  • Natural history

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lynch, H. T., Smyrk, T. C., Lanspa, S. J., Jenkins, J. X., Cavalieri, J., & Lynch, J. F. (1993). Cancer control problems in the lynch syndromes. Diseases of the Colon and Rectum, 36(3), 254-260.

Cancer control problems in the lynch syndromes. / Lynch, H. T.; Smyrk, Thomas Christopher; Lanspa, S. J.; Jenkins, J. X.; Cavalieri, J.; Lynch, J. F.

In: Diseases of the Colon and Rectum, Vol. 36, No. 3, 1993, p. 254-260.

Research output: Contribution to journalArticle

Lynch, HT, Smyrk, TC, Lanspa, SJ, Jenkins, JX, Cavalieri, J & Lynch, JF 1993, 'Cancer control problems in the lynch syndromes', Diseases of the Colon and Rectum, vol. 36, no. 3, pp. 254-260.
Lynch HT, Smyrk TC, Lanspa SJ, Jenkins JX, Cavalieri J, Lynch JF. Cancer control problems in the lynch syndromes. Diseases of the Colon and Rectum. 1993;36(3):254-260.
Lynch, H. T. ; Smyrk, Thomas Christopher ; Lanspa, S. J. ; Jenkins, J. X. ; Cavalieri, J. ; Lynch, J. F. / Cancer control problems in the lynch syndromes. In: Diseases of the Colon and Rectum. 1993 ; Vol. 36, No. 3. pp. 254-260.
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