Cancer based pharmacogenomics network for drug repurposing

Liwei Wang, Hongfang D Liu, Christopher G. Chute, Qian Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Pharmacogenomics (PGx) as an emerging field, is poised to change the way we practice medicine and deliver health care by customizing drug therapies on the basis of each patient’s genetic makeup. A large volume of PGx data including information on relationships among drugs, genes, and single nucleotide polymorphisms (SNPs) has been accumulated. Normalized and integrated PGx information could facilitate revelation of hidden relationships among drug treatments, genomic variations, and phenotype traits to better support drug discovery and next generation of treatment. In this study, we constructed a normalized cancer based PGx network (CPN) by integrating cancer orientated PGx information from multiple well known PGx resources including the Pharmacogenomics Knowledge Base (PharmGKB), the FDA Pharmacogenomic Biomarkers in Drug Labeling, and the Catalog of Published Genome-Wide Association Studies. The ultimate goal of the CPN is to provide comprehensive cancer specific PGx information to support oncology related research, including cancer based drug discovery – drug repurposing. We have successfully demonstrated the capability of the CPN for drug repurposing by conducting two case studies.

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8643
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

OtherInternational Workshops on Data Mining and Decision Analytics for Public Health, Biologically Inspired Data Mining Techniques, Mobile Data Management, Mining, and Computing on Social Networks, Big Data Science and Engineering on E-Commerce, Cloud Service Discovery, MSMV-MBI, Scalable Dats Analytics, Data Mining and Decision Analytics for Public Health and Wellness, Algorithms for Large-Scale Information Processing in Knowledge Discovery, Data Mining in Social Networks, Data Mining in Biomedical informatics and Healthcare, Pattern Mining and Application of Big Data in conjunction with 18th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2014
CountryTaiwan, Province of China
CityTainan
Period5/13/145/16/14

Fingerprint

Drug therapy
Cancer
Drugs
Genes
Drug Discovery
Oncology
Biomarkers
Nucleotides
Polymorphism
Health care
Labeling
Medicine
Single nucleotide Polymorphism
Phenotype
Knowledge Base
Healthcare
Therapy
Genomics
Pharmacogenetics
Genome

Keywords

  • Cancer
  • Drug repurposing
  • Network
  • Pharmacogenomics

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Wang, L., Liu, H. D., Chute, C. G., & Zhu, Q. (2014). Cancer based pharmacogenomics network for drug repurposing. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 8643, pp. 639-651). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8643). Springer Verlag. https://doi.org/10.1007/978-3-319-13186-3_57

Cancer based pharmacogenomics network for drug repurposing. / Wang, Liwei; Liu, Hongfang D; Chute, Christopher G.; Zhu, Qian.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 8643 Springer Verlag, 2014. p. 639-651 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8643).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, L, Liu, HD, Chute, CG & Zhu, Q 2014, Cancer based pharmacogenomics network for drug repurposing. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 8643, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 8643, Springer Verlag, pp. 639-651, International Workshops on Data Mining and Decision Analytics for Public Health, Biologically Inspired Data Mining Techniques, Mobile Data Management, Mining, and Computing on Social Networks, Big Data Science and Engineering on E-Commerce, Cloud Service Discovery, MSMV-MBI, Scalable Dats Analytics, Data Mining and Decision Analytics for Public Health and Wellness, Algorithms for Large-Scale Information Processing in Knowledge Discovery, Data Mining in Social Networks, Data Mining in Biomedical informatics and Healthcare, Pattern Mining and Application of Big Data in conjunction with 18th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2014, Tainan, Taiwan, Province of China, 5/13/14. https://doi.org/10.1007/978-3-319-13186-3_57
Wang L, Liu HD, Chute CG, Zhu Q. Cancer based pharmacogenomics network for drug repurposing. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 8643. Springer Verlag. 2014. p. 639-651. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-13186-3_57
Wang, Liwei ; Liu, Hongfang D ; Chute, Christopher G. ; Zhu, Qian. / Cancer based pharmacogenomics network for drug repurposing. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 8643 Springer Verlag, 2014. pp. 639-651 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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