Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn's Disease

Remo Panaccione, A. Hillary Steinhart, B. Bressler, R. Khanna, John K. Marshall, L. Targownik, Waqqas Afif, A. Bitton, Mark Borgaonkar, Usha Chauhan, Brendan Halloran, Jennifer Jones, Erin Kennedy, Grigorios I. Leontiadis, Edward V. Loftus, Jonathan Meddings, Paul Moayyedi, Sanjay Murthy, Sophie Plamondon, Greg RosenfeldD. Schwartz, Cynthia H. Seow, Chadwick Williams, Charles N. Bernstein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background & Aims: Crohn's disease (CD) is a lifelong illness with substantial morbidity, although new therapies and treatment paradigms have been developed. We provide guidance for treatment of ambulatory patients with mild to severe active luminal CD. Methods: We performed a systematic review to identify published studies of the management of CD. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. Statements were developed through an iterative online platform and then finalized and voted on by a group of specialists. Results: The consensus includes 41 statements focused on 6 main drug classes: antibiotics, 5-aminosalicylate, corticosteroids, immunosuppressants, biologic therapies, and other therapies. The group suggested against the use of antibiotics or 5-aminosalicylate as induction or maintenance therapies. Corticosteroid therapies (including budesonide) can be used as induction, but not maintenance therapies. Among immunosuppressants, thiopurines should not be used for induction, but can be used for maintenance therapy for selected low-risk patients. Parenteral methotrexate was proposed for induction and maintenance therapy in patients with corticosteroid-dependent CD. Biologic agents, including tumor necrosis factor antagonists, vedolizumab, and ustekinumab, were recommended for patients failed by conventional induction therapies and as maintenance therapy. The consensus group was unable to clearly define the role of concomitant immunosuppressant therapies in initiation of treatment with a biologic agent. Conclusions: Optimal management of CD requires careful patient assessment, acknowledgement of patient preferences, evidence-based use of existing therapies, and thorough assessment to define treatment success.

Original languageEnglish (US)
Pages (from-to)1680-1713
Number of pages34
JournalClinical Gastroenterology and Hepatology
Volume17
Issue number9
DOIs
StatePublished - Aug 2019

Keywords

  • 5-ASA
  • Guidance
  • Mucosal Healing
  • TNF

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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