Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease

Maria C. Carrillo; H. Robert Brashear; Veronika Logovinsky; J. Michael Ryan; Howard H. Feldman; Eric R. Siemers; Susan Abushakra; Dean M. Hartley; Ronald C. Petersen; Ara S. Khachaturian; Reisa A. Sperling

doi:10.1016/j.jalz.2012.12.004

Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease

Maria C. Carrillo, H. Robert Brashear, Veronika Logovinsky, J. Michael Ryan, Howard H. Feldman, Eric R. Siemers, Susan Abushakra, Dean M. Hartley, Ronald C. Petersen, Ara S. Khachaturian, Reisa A. Sperling

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.

Original language	English (US)
Pages (from-to)	123-131.e1
Journal	Alzheimer's and Dementia
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2012.12.004
State	Published - Mar 2013

Keywords

Alzheimer's disease
Diagnosis
Mild cognitive impairment
Preclinical Alzheimer's
Prevention

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

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10.1016/j.jalz.2012.12.004

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abstract = "Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.",

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AU - Carrillo, Maria C.

AU - Brashear, H. Robert

AU - Logovinsky, Veronika

AU - Ryan, J. Michael

AU - Feldman, Howard H.

AU - Siemers, Eric R.

AU - Abushakra, Susan

AU - Hartley, Dean M.

AU - Petersen, Ronald C.

AU - Khachaturian, Ara S.

AU - Sperling, Reisa A.

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KW - Mild cognitive impairment

KW - Preclinical Alzheimer's

KW - Prevention

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Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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