Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease

Maria C. Carrillo, H. Robert Brashear, Veronika Logovinsky, J. Michael Ryan, Howard H. Feldman, Eric R. Siemers, Susan Abushakra, Dean M. Hartley, Ronald Carl Petersen, Ara S. Khachaturian, Reisa A. Sperling

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalAlzheimer's and Dementia
Volume9
Issue number2
DOIs
StatePublished - Mar 2013

Fingerprint

Secondary Prevention
Alzheimer Disease
National Institute on Aging (U.S.)
Research
Asymptomatic Diseases
Primary Prevention

Keywords

  • Alzheimer's disease
  • Diagnosis
  • Mild cognitive impairment
  • Preclinical Alzheimer's
  • Prevention

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Carrillo, M. C., Brashear, H. R., Logovinsky, V., Ryan, J. M., Feldman, H. H., Siemers, E. R., ... Sperling, R. A. (2013). Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimer's and Dementia, 9(2), 123-131. https://doi.org/10.1016/j.jalz.2012.12.004

Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. / Carrillo, Maria C.; Brashear, H. Robert; Logovinsky, Veronika; Ryan, J. Michael; Feldman, Howard H.; Siemers, Eric R.; Abushakra, Susan; Hartley, Dean M.; Petersen, Ronald Carl; Khachaturian, Ara S.; Sperling, Reisa A.

In: Alzheimer's and Dementia, Vol. 9, No. 2, 03.2013, p. 123-131.

Research output: Contribution to journalArticle

Carrillo, MC, Brashear, HR, Logovinsky, V, Ryan, JM, Feldman, HH, Siemers, ER, Abushakra, S, Hartley, DM, Petersen, RC, Khachaturian, AS & Sperling, RA 2013, 'Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease', Alzheimer's and Dementia, vol. 9, no. 2, pp. 123-131. https://doi.org/10.1016/j.jalz.2012.12.004
Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER et al. Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimer's and Dementia. 2013 Mar;9(2):123-131. https://doi.org/10.1016/j.jalz.2012.12.004
Carrillo, Maria C. ; Brashear, H. Robert ; Logovinsky, Veronika ; Ryan, J. Michael ; Feldman, Howard H. ; Siemers, Eric R. ; Abushakra, Susan ; Hartley, Dean M. ; Petersen, Ronald Carl ; Khachaturian, Ara S. ; Sperling, Reisa A. / Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. In: Alzheimer's and Dementia. 2013 ; Vol. 9, No. 2. pp. 123-131.
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