Can treating depression reduce mortality after an acute myocardial infarction?

Robert M. Carney, Kenneth E. Freedland, Richard C. Veith, Allan S Jaffe

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Major depression affects about one in five patients in the weeks after an acute myocardial infarction and is associated with an increased risk of cardiac morbidity and mortality. Consequently, there is considerable interest in the question of whether treating depression will improve medical prognosis in these patients. Safe, effective treatments for depression are available, but unless they also improve the underlying pathophysiological or behavioral mechanisms that contribute to cardiac morbidity and mortality, they may not have beneficial effects on prognosis. Altered cardiac autonomic tone is one of the leading candidate mechanisms. Unfortunately, a review of the available research reveals that cardiac autonomic tone often fails to normalize in patients treated for depression, and the research suggests that currently available treatments for depression will not necessarily improve cardiac event-free survival in patients who have had an acute myocardial infarction. Until there is convincing evidence that treatment can reduce the risk of cardiac morbidity and mortality, the principal reason to treat depression should continue to be to improve the quality of life of the patient who has had an acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)666-675
Number of pages10
JournalPsychosomatic Medicine
Volume61
Issue number5
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Myocardial Infarction
Mortality
Morbidity
Research
Disease-Free Survival
Therapeutics
Quality of Life

Keywords

  • Coronary heart disease
  • Depression
  • Mortality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Can treating depression reduce mortality after an acute myocardial infarction? / Carney, Robert M.; Freedland, Kenneth E.; Veith, Richard C.; Jaffe, Allan S.

In: Psychosomatic Medicine, Vol. 61, No. 5, 09.1999, p. 666-675.

Research output: Contribution to journalArticle

Carney, RM, Freedland, KE, Veith, RC & Jaffe, AS 1999, 'Can treating depression reduce mortality after an acute myocardial infarction?', Psychosomatic Medicine, vol. 61, no. 5, pp. 666-675.
Carney, Robert M. ; Freedland, Kenneth E. ; Veith, Richard C. ; Jaffe, Allan S. / Can treating depression reduce mortality after an acute myocardial infarction?. In: Psychosomatic Medicine. 1999 ; Vol. 61, No. 5. pp. 666-675.
@article{c111633baf744e8bb40b7d2264b59687,
title = "Can treating depression reduce mortality after an acute myocardial infarction?",
abstract = "Major depression affects about one in five patients in the weeks after an acute myocardial infarction and is associated with an increased risk of cardiac morbidity and mortality. Consequently, there is considerable interest in the question of whether treating depression will improve medical prognosis in these patients. Safe, effective treatments for depression are available, but unless they also improve the underlying pathophysiological or behavioral mechanisms that contribute to cardiac morbidity and mortality, they may not have beneficial effects on prognosis. Altered cardiac autonomic tone is one of the leading candidate mechanisms. Unfortunately, a review of the available research reveals that cardiac autonomic tone often fails to normalize in patients treated for depression, and the research suggests that currently available treatments for depression will not necessarily improve cardiac event-free survival in patients who have had an acute myocardial infarction. Until there is convincing evidence that treatment can reduce the risk of cardiac morbidity and mortality, the principal reason to treat depression should continue to be to improve the quality of life of the patient who has had an acute myocardial infarction.",
keywords = "Coronary heart disease, Depression, Mortality",
author = "Carney, {Robert M.} and Freedland, {Kenneth E.} and Veith, {Richard C.} and Jaffe, {Allan S}",
year = "1999",
month = "9",
language = "English (US)",
volume = "61",
pages = "666--675",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Can treating depression reduce mortality after an acute myocardial infarction?

AU - Carney, Robert M.

AU - Freedland, Kenneth E.

AU - Veith, Richard C.

AU - Jaffe, Allan S

PY - 1999/9

Y1 - 1999/9

N2 - Major depression affects about one in five patients in the weeks after an acute myocardial infarction and is associated with an increased risk of cardiac morbidity and mortality. Consequently, there is considerable interest in the question of whether treating depression will improve medical prognosis in these patients. Safe, effective treatments for depression are available, but unless they also improve the underlying pathophysiological or behavioral mechanisms that contribute to cardiac morbidity and mortality, they may not have beneficial effects on prognosis. Altered cardiac autonomic tone is one of the leading candidate mechanisms. Unfortunately, a review of the available research reveals that cardiac autonomic tone often fails to normalize in patients treated for depression, and the research suggests that currently available treatments for depression will not necessarily improve cardiac event-free survival in patients who have had an acute myocardial infarction. Until there is convincing evidence that treatment can reduce the risk of cardiac morbidity and mortality, the principal reason to treat depression should continue to be to improve the quality of life of the patient who has had an acute myocardial infarction.

AB - Major depression affects about one in five patients in the weeks after an acute myocardial infarction and is associated with an increased risk of cardiac morbidity and mortality. Consequently, there is considerable interest in the question of whether treating depression will improve medical prognosis in these patients. Safe, effective treatments for depression are available, but unless they also improve the underlying pathophysiological or behavioral mechanisms that contribute to cardiac morbidity and mortality, they may not have beneficial effects on prognosis. Altered cardiac autonomic tone is one of the leading candidate mechanisms. Unfortunately, a review of the available research reveals that cardiac autonomic tone often fails to normalize in patients treated for depression, and the research suggests that currently available treatments for depression will not necessarily improve cardiac event-free survival in patients who have had an acute myocardial infarction. Until there is convincing evidence that treatment can reduce the risk of cardiac morbidity and mortality, the principal reason to treat depression should continue to be to improve the quality of life of the patient who has had an acute myocardial infarction.

KW - Coronary heart disease

KW - Depression

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=0032883976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032883976&partnerID=8YFLogxK

M3 - Article

C2 - 10511015

AN - SCOPUS:0032883976

VL - 61

SP - 666

EP - 675

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 5

ER -