Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected Submucosal Esophageal Adenocarcinomas? A Multi-Center Study

Joshua A. Boys, Stephanie G. Worrell, Parakrama Chandrasoma, John G. Vallone, Dipen M. Maru, Lizhi Zhang, Shanda H. Blackmon, Karen J. Dickinson, Christy M. Dunst, Wayne L. Hofstetter, Michael J. Lada, Brian E. Louie, Daniela Molena, Thomas J. Watson, Steven R. DeMeester

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Endoscopic resection (ER) allows for local therapy of superficial esophageal cancers. Factors reported to be associated with an increased risk of lymph node metastases in patients with adenocarcinoma are poor differentiation, lymphovascular invasion (LVI), and submucosal invasion >500 μ. The aim of this study was to determine whether depth of invasion and tumor characteristics in an ER specimen can be used to gauge the risk of lymph node metastases in patients with superficial esophageal adenocarcinoma. Patients from seven US centers that had ER of an adenocarcinoma followed by an esophagectomy were identified. The ER pathology slides were rereviewed by three experienced GI pathologists for depth of invasion, presence of LVI, and tumor differentiation. The findings from the ER specimen were correlated with the presence and number of lymph node metastases in the final esophagectomy specimen. There were 19 T1a and 23 T1b tumors. A median of 24 nodes were resected per patient. None of the T1a tumors had involved lymph nodes despite the presence of LVI in 5 % and poor differentiation in 21 % of patients. In contrast, 26 % of T1b tumors had involved nodes. None of the four patients with submucosal invasion ≤500 μ, no LVI, and no poor differentiation had involved nodes. However, with an increasing number of risk factors, the likelihood of involved lymph nodes increased, reaching 50 % when all three factors were present. Endoscopic therapy appears appropriate for intramucosal tumors and may be an option for low-risk T1b tumors. Esophagectomy is preferred for patients with submucosal invasion and one or more risk factors.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2016

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Adenocarcinoma
Lymph Nodes
Neoplasm Metastasis
Esophagectomy
Neoplasms
Esophageal Neoplasms
Pathology
Therapeutics

Keywords

  • Barrett’s esophagus
  • Endoscopic resection
  • Esophageal adenocarcinoma
  • Esophagectomy

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected Submucosal Esophageal Adenocarcinomas? A Multi-Center Study. / Boys, Joshua A.; Worrell, Stephanie G.; Chandrasoma, Parakrama; Vallone, John G.; Maru, Dipen M.; Zhang, Lizhi; Blackmon, Shanda H.; Dickinson, Karen J.; Dunst, Christy M.; Hofstetter, Wayne L.; Lada, Michael J.; Louie, Brian E.; Molena, Daniela; Watson, Thomas J.; DeMeester, Steven R.

In: Journal of Gastrointestinal Surgery, Vol. 20, No. 1, 01.01.2016, p. 6-12.

Research output: Contribution to journalArticle

Boys, JA, Worrell, SG, Chandrasoma, P, Vallone, JG, Maru, DM, Zhang, L, Blackmon, SH, Dickinson, KJ, Dunst, CM, Hofstetter, WL, Lada, MJ, Louie, BE, Molena, D, Watson, TJ & DeMeester, SR 2016, 'Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected Submucosal Esophageal Adenocarcinomas? A Multi-Center Study', Journal of Gastrointestinal Surgery, vol. 20, no. 1, pp. 6-12. https://doi.org/10.1007/s11605-015-2950-9
Boys, Joshua A. ; Worrell, Stephanie G. ; Chandrasoma, Parakrama ; Vallone, John G. ; Maru, Dipen M. ; Zhang, Lizhi ; Blackmon, Shanda H. ; Dickinson, Karen J. ; Dunst, Christy M. ; Hofstetter, Wayne L. ; Lada, Michael J. ; Louie, Brian E. ; Molena, Daniela ; Watson, Thomas J. ; DeMeester, Steven R. / Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected Submucosal Esophageal Adenocarcinomas? A Multi-Center Study. In: Journal of Gastrointestinal Surgery. 2016 ; Vol. 20, No. 1. pp. 6-12.
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abstract = "Endoscopic resection (ER) allows for local therapy of superficial esophageal cancers. Factors reported to be associated with an increased risk of lymph node metastases in patients with adenocarcinoma are poor differentiation, lymphovascular invasion (LVI), and submucosal invasion >500 μ. The aim of this study was to determine whether depth of invasion and tumor characteristics in an ER specimen can be used to gauge the risk of lymph node metastases in patients with superficial esophageal adenocarcinoma. Patients from seven US centers that had ER of an adenocarcinoma followed by an esophagectomy were identified. The ER pathology slides were rereviewed by three experienced GI pathologists for depth of invasion, presence of LVI, and tumor differentiation. The findings from the ER specimen were correlated with the presence and number of lymph node metastases in the final esophagectomy specimen. There were 19 T1a and 23 T1b tumors. A median of 24 nodes were resected per patient. None of the T1a tumors had involved lymph nodes despite the presence of LVI in 5 {\%} and poor differentiation in 21 {\%} of patients. In contrast, 26 {\%} of T1b tumors had involved nodes. None of the four patients with submucosal invasion ≤500 μ, no LVI, and no poor differentiation had involved nodes. However, with an increasing number of risk factors, the likelihood of involved lymph nodes increased, reaching 50 {\%} when all three factors were present. Endoscopic therapy appears appropriate for intramucosal tumors and may be an option for low-risk T1b tumors. Esophagectomy is preferred for patients with submucosal invasion and one or more risk factors.",
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AU - Vallone, John G.

AU - Maru, Dipen M.

AU - Zhang, Lizhi

AU - Blackmon, Shanda H.

AU - Dickinson, Karen J.

AU - Dunst, Christy M.

AU - Hofstetter, Wayne L.

AU - Lada, Michael J.

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