Can mechanically stimulated airway epithelial cells regulate fibroblast activity?

M. Swartz, D. Tschumperlin, B. Ressler, R. Kamm, J. Drazen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated the ability of mechanically stress airway epithelial cells to elicit matrix remodeling in co-cultured fibroblasts. Fibroblast signalling molecules in epithelial cells were found to be sensitive to mechanical stress in the form of transepithelial pressure and solid stress. Also, co-cultured fibroblasts responded to stressed epithelial cells by altering their secretion of airway remodeling proteins. Mechanisms of transduction were suggested according to the response to varying types and conditions of stress application. This study shows that airway remodeling in asthma may be due, in part, to the mechanical stresses experienced by epithelial cells in constricted, buckled airways.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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