TY - JOUR
T1 - Can loratadine help in treating granulocyte-colony stimulating factor-induced bone pain?
AU - Gajarawala, Shilpa N.
AU - Pelkowski, Jessica N.
AU - Destephano, Christopher C.
N1 - Publisher Copyright:
© 2021 American Academy of Physician Assistants.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Febrile neutropenia is an oncologic emergency with serious consequences. Granulocyte colony stimulating factors (G-CSFs), used to stimulate neutrophil production to prevent febrile neutropenia, can cause bone pain in more than 25% of patients. Severe bone pain may not respond to acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, or dose reduction of the G-CSF agent. A study found that patients taking loratadine had fewer treatment-associated adverse reactions and discontinuations than those on naproxen. Although more research is needed, loratadine's tolerability, ease of administration, and potential benefit mean that it should be considered for management of pegfilgrastim-associated bone pain. This article describes a patient whose G-CSF-induced bone pain was completely alleviated by loratadine.
AB - Febrile neutropenia is an oncologic emergency with serious consequences. Granulocyte colony stimulating factors (G-CSFs), used to stimulate neutrophil production to prevent febrile neutropenia, can cause bone pain in more than 25% of patients. Severe bone pain may not respond to acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, or dose reduction of the G-CSF agent. A study found that patients taking loratadine had fewer treatment-associated adverse reactions and discontinuations than those on naproxen. Although more research is needed, loratadine's tolerability, ease of administration, and potential benefit mean that it should be considered for management of pegfilgrastim-associated bone pain. This article describes a patient whose G-CSF-induced bone pain was completely alleviated by loratadine.
KW - antihistamine
KW - bone pain
KW - filgrastim
KW - granulocyte colony stimulating factor
KW - loratadine
KW - pegfilgrastim
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U2 - 10.1097/01.JAA.0000753896.78290.12
DO - 10.1097/01.JAA.0000753896.78290.12
M3 - Article
C2 - 34162806
AN - SCOPUS:85109055704
SN - 1547-1896
VL - 34
SP - 29
EP - 31
JO - Journal of the American Academy of Physician Assistants
JF - Journal of the American Academy of Physician Assistants
IS - 7
ER -